April 15 – Joseph E. Seagram, distillery founder, politician, philanthropist and racehorse owner (died 1919)
April 21 – Jennie Kidd Trout, physician, first woman in Canada legally to become a medical doctor and only woman in Canada licensed to practice medicine until 1880 (died 1921)
Oronhyatekha, Mohawk physician, CEO of an international benefit society, native statesman, scholar, rights campaigner and international shooter (died 1907)