July 18 – American Civil War: The first formal African American military unit, the 54th Massachusetts Volunteer Infantry, unsuccessfully assaults Confederate-held Fort Wagner but their valiant fighting still proves the worth of African American soldiers during the war. Their commander, Colonel Robert Shaw is shot leading the attack and was buried with his men (450 Union, 175 Confederate).
July 30 – Indian Wars: Chief Pocatello of the Shoshone tribe signs the Treaty of Box Elder, promising to stop harassing the emigrant trails in southern Idaho and northern Utah.
August 8 – American Civil War: Following his defeat in the Battle of Gettysburg, General Robert E. Lee sends a letter of resignation to Confederate President Jefferson Davis (Davis refuses the request upon receipt).
"Four score and seven years ago our fathers brought forth on this continent, a new nation, conceived in Liberty, and dedicated to the proposition that all men are created equal. Now we are engaged in a great civil war, testing whether that nation or any nation so conceived and so dedicated, can long endure."
November 17 – American Civil War – The Siege of Knoxville begins: Confederate forces led by General James Longstreet place Knoxville, Tennessee under siege (the 2-week-long siege and 1 failed attack are unsuccessful).
November 23 – American Civil War – The Battle of Chattanooga III begins: Union forces led by General Ulysses S. Grant reinforce troops at Chattanooga, Tennessee and counter-attack Confederate troops.
November 24 – American Civil War – Battle of Lookout Mountain: Near Chattanooga, Tennessee, Union forces under General Ulysses S. Grant capture Lookout Mountain and begin to break the Confederate siege of the city led by General Braxton Bragg.
November 26 – American Civil War – Battle of Mine Run: Union forces under General George Meade position against troops led by Confederate General Robert E. Lee (Meade's forces can not find any weaknesses in the Confederate lines and give up trying after 5 days).
November 27 – American Civil War: Confederate cavalry leader John Hunt Morgan and several of his men escape the Ohio state prison, and return safely to the South.
^Reynolds, Moira Davison (2004). American Women Scientists: 23 Inspiring Biographies, 1900-2000. Jefferson NC: McFarland. p. 18. ISBN978-0-78642-161-9.