The 1905 American Medical football team was an American football team that represented the American College of Medicine and Surgery of Chicago, now a part of Loyola University of Chicago in the 1905 college football season. It is likely that American Medical played more contests, but no more against major college teams. In their single known major collegiate contest, American Medical suffered one of the most lopsided defeats in the history of college football, a 142–0 count against Notre Dame. This was the last year American Medical fielded a football team.[1][2]