American college football season
The 2003 Iowa State Cyclones football team represented Iowa State University as a member of the North Division of the Big 12 Conference during the 2003 NCAA Division I-A football season. Led by ninth-year head coach Dan McCarney, the Cyclones combined an overall record of 2–10 with a mark of 0–8 in conference play, placing last out of six teams in the Big 12's North Division. The team played home games at Jack Trice Stadium in Ames, Iowa.
| Date | Time | Opponent | Site | TV | Result | Attendance |
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| August 30 | 6:00 p.m. | Northern Iowa* | | | W 17–10 | 48,088 |
| September 6 | 1:00 p.m. | Ohio* | - Jack Trice Stadium
- Ames, IA
| | W 48–20 | 40,056 |
| September 13 | 11:30 a.m. | No. 23 Iowa* | - Jack Trice Stadium
- Ames, IA (rivalry)
| FSN | L 21–40 | 53,486 |
| September 27 | 3:05 p.m. | at No. 20 Northern Illinois* | | | L 16–24 | 28,218 |
| October 4 | 6:00 p.m. | No. 1 Oklahoma | - Jack Trice Stadium
- Ames, IA
| TBS | L 7–53 | 49,670 |
| October 11 | 6:00 p.m. | at Texas Tech | | | L 21–52 | 49,627 |
| October 18 | 11:30 a.m. | No. 20 Texas | - Jack Trice Stadium
- Ames, IA
| PPV | L 19–40 | 45,355 |
| October 25 | 11:30 a.m. | at No. 14 Nebraska | | PPV | L 0–28 | 77,483 |
| November 8 | 1:00 p.m. | Kansas State | - Jack Trice Stadium
- Ames, IA (rivalry)
| | L 0–45 | 40,124 |
| November 15 | 1:00 p.m. | Colorado | - Jack Trice Stadium
- Ames, IA
| | L 10–44 | 36,977 |
| November 22 | 1:00 p.m. | at Kansas | | | L 7–36 | 34,518 |
| November 29 | Noon | at Missouri | | ABC | L 7–45 | 46,435 |
- *Non-conference game
Homecoming- Rankings from AP Poll released prior to the game
- All times are in Central time
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