16 April – Dominique Voynet, Director of Mayotte Regional Health Agency, announced that a person who died on 8 April before being evacuated to Mayotte on the basis of a x-ray of COVID-19 was Said Toihir, the Grand Mufti of the country.[2] The announcement caused a diplomatic rift between the country and France. Mohamed El-Amine Souef, the Foreign Minister, said "If a case is confirmed in the Comoros, it is not Dominique Voynet to announce it, we have been independent since 6 July 1975."[3]
22 April – A polymerase chain reaction (PCR) screening machine was delivered to the country, allowing for COVID-19 testing the country starting on 23 April.[5]
30 April – The first case of COVID-19 in the country was confirmed: a 50-year-old man who was admitted to the El-Maarouf hospital in Moroni on 23 April. The patient had been in contact with a Franco-Comorian national on 18 March. As a result of the confirmation, President Azali Assoumani disclosed that a curfew had been instituted.[6][7][8]
2 May – A video conference was held between President Assoumani and President Rajoelina of Madagascar. Madagascar will send medical aid to the country.[9]
4 May – The first COVID-19 death in the country was reported.[10]
6 May – President Azali Assoumani announced that total confinement is not an option for the islands. A donation of 100,000 face masks had been received, and India will be sending medical supplies and doctors to support the local health care.[11]
13 May – The United Nations donated 1,000 rapid tests to the Ministry of Health.[13]
16 May – The first repatriation flight arrived from Tanzania with 134 people on board, with 70 people returned from Kenya. Two more flights are planned to arrive from Tanzania on 17 May.[14]
19 May – The presence of COVID-19 on Anjouan (Ngazidja) was confirmed, making the virus now active on all major islands.[15]
21 May – The Grand Mufti requested that the people celebrate Eid al-Fitr at home as a result of the pandemic.[16]