Nikoloz Basilashvili defeated Roberto Bautista Agut in the final, 7–6(7–5), 6–2 to win the men's singles tennis title at the 2021 Qatar Open. Basilashvili saved a match point against Roger Federer in the quarterfinals.
Andrey Rublev was the defending champion, but lost in the semifinals to Bautista Agut.[1]
This tournament marked the return of former world No. 1 Federer to the tour for the first time since the 2020 Australian Open, due to a pair of knee surgeries since then.[2] His defeat to Basilashvili marked a record-extending 24th and final loss from match point up in his career.