10 January – Uganda reopens schools for the first time since March 2020 after a nearly two-year closure due to the COVID-19 pandemic.[1]
28 January – The Rwandan foreign ministry announces the reopening of the country's border crossing with Uganda following political tensions between the two countries that led to the closure of the border crossing for three years.[2]
4 May – Twenty people are killed when a bus crashes into a tea estate in Fort Portal.[3]
24 May – Ugandan police arrest veteran opposition politician Kizza Besigye for "inciting violence" and also disperse a crowd protesting against the government.[4]
8 June – Uganda reports its first suspected case of monkeypox.[5]
1 August – Twenty-four people are killed by heavy flooding in eastern Uganda.[6]
20 September – 2022 Uganda Ebola outbreak: Uganda reports an outbreak of Ebola after a rare case of the Sudan ebolavirus strain was confirmed in a 24-year-old man who later died, becoming the first known fatality from the strain since 2011.[8]
17 October – 2022 Uganda Ebola outbreak: President Yoweri Museveni places the capital city of Kampala under high Ebola response alert after two non-native patients reached the city, one of whom died, amid an outbreak of the disease in the country.[9]