25 January – Millions of people are left without electricity after a major power outage affects Kazakhstan, Kyrgyzstan and Uzbekistan. Uzbekistan's energy ministry reports that the power outage had been triggered by an "energy imbalance" in Kazakhstan's power grid.[1]
1 July – Protests occur in the autonomous Uzbekistani region of Karakalpakstan against a proposed constitutional change that would strip the region of its autonomy.[2]
2 July – 2022 Karakalpak protests: The government of Uzbekistan drops plans to strip Karakalpakstan of its autonomy amid widespread protests in the region. Internet access is restricted as regional protests continue for a second day, with the government accusing a "criminal gang" of trying to seize government buildings in Karakalpakstan.[3]
5 July – Five rockets are fired into Uzbekistan from Afghanistan, landing in the city of Termez. Government officials report that none of the missiles exploded and that minor damage occurred to four homes.[6]
10 August – Uzbekistan's embassy in Russia warns its citizens not to join Russian forces invading Ukraine, saying that those who do so will be criminally liable for mercenaryism upon returning to Uzbekistan.[8]
25 September – Uzbekistan suspends the use of Russia's card payment systemMir. The move was supposedly warranted by the need "to carry out the necessary technical procedures" and was not related to sanctions.[9]