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3(or 17)a-hydroxysteroid dehydrogenase
From Wikipedia - Reading time: 6 min
| 3(or 17)alpha-hydroxysteroid dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.209 | ||||||||
| CAS no. | 83294-77-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3(or 17)alpha-hydroxysteroid dehydrogenase (EC 1.1.1.209, 3(17)alpha-hydroxysteroid dehydrogenase) is an enzyme with systematic name 3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase.[1][2] This enzyme catalyses the chemical reaction
- androsterone + NAD(P)+ 5alpha-androstane-3,17-dione + NAD(P)H + H+
This enzyme acts on the 3alpha-hydroxy group of androgens of the 5alpha-androstane series; and also, more slowly, on the 17alpha-hydroxy group of both androgenic and estrogenic substrates (cf. EC 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase).
References
[edit]- ^ Lau PC, Layne DS, Williamson DG (August 1982). "A 3(17) alpha-hydroxysteroid dehydrogenase of female rabbit kidney cytosol. Purification and characterization of multiple forms of the enzyme". The Journal of Biological Chemistry. 257 (16): 9444–9. doi:10.1016/S0021-9258(18)34090-0. PMID 6955302.
- ^ Lau PC, Layne DS, Williamson DG (August 1982). "Comparison of the multiple forms of the soluble 3(17) alpha-hydroxysteroid dehydrogenases of female rabbit kidney and liver". The Journal of Biological Chemistry. 257 (16): 9450–6. doi:10.1016/S0021-9258(18)34091-2. PMID 6955303.
External links
[edit]- 3(or+17)alpha-hydroxysteroid+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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