AACS (gene)

AACS
Identifiers
Aliases	AACS, ACSF1, SUR-5, acetoacetyl-CoA synthetase
External IDs	OMIM: 614364; MGI: 1926144; HomoloGene: 11322; GeneCards: AACS; OMA:AACS - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	125,143,333 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	125,594,474 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; gingival epithelium; ; skin of arm; ; nipple; ; middle temporal gyrus; ; vulva; ; trachea; ; tibia; ; human penis; ; skin of thigh;
	Top expressed in
	right kidney; ; tunica adventitia of aorta; ; granulocyte; ; proximal tubule; ; lumbar spinal ganglion; ; lip; ; brown adipose tissue; ; trachea; ; white adipose tissue; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; butyrate-CoA ligase activity; ligase activity; protein binding; catalytic activity; ATP binding; acetoacetate-CoA ligase activity;
Cellular component	cytoplasm; cytosol;
Biological process	response to organic cyclic compound; response to nutrient; lipid metabolism; cellular response to testosterone stimulus; cellular response to cholesterol; fatty acid metabolic process; response to purine-containing compound; ketone body biosynthetic process; response to organonitrogen compound; response to starvation; white fat cell differentiation; liver development; adipose tissue development; metabolism; response to ethanol; cellular response to glucose stimulus; response to oleic acid; positive regulation of insulin secretion;
	Sources:Amigo / QuickGO
Orthologs
	65985
	78894
	ENSG00000081760
	ENSMUSG00000029482
	Q86V21
	Q9D2R0
	NM_023928; NM_001319839; NM_001319840
	NM_030210
	NP_001306768; NP_001306769; NP_076417
	NP_084486
	Wikidata
View/Edit Human	View/Edit Mouse

The acetoacetyl-CoA synthetase (AACS) gene encodes a protein of the same name, which converts acetoacetate to acetoacetyl-CoA, and plays a crucial role in ketone body utilization and fatty acid synthesis. The gene is found on human chromosome 12.

The AACS protein is a member of the acetyl-CoA synthetase family and is involved in cellular energy production, ketogenesis, and cholesterol synthesis.^[5] It is expressed in a wide range of human tissues.^[6]

Function

The protein's function is regulated transcriptionally by sterol regulatory element-binding protein (SREBP) and peroxisome proliferator-activated receptor gamma (PPARγ).^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000081760 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029482 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Q86V21 · AACS_HUMAN". www.uniprot.org. Uniprot. Retrieved 2023-12-09.
^ "AACS acetoacetyl-CoA synthetase". www.ncbi.nlm.nih.gov. NCBI Gene. Retrieved 2023-12-09.
^ Aguiló F, Camarero N, Relat J, Marrero PF, Haro D (March 2010). "Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma" (PDF). The Biochemical Journal. 427 (2): 255–264. doi:10.1042/bj20090851. PMID 20102333. S2CID 1043396.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000081760 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029482 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Q86V21 · AACS_HUMAN". www.uniprot.org. Uniprot. Retrieved 2023-12-09.

[6] "AACS acetoacetyl-CoA synthetase". www.ncbi.nlm.nih.gov. NCBI Gene. Retrieved 2023-12-09.

[7] Aguiló F, Camarero N, Relat J, Marrero PF, Haro D (March 2010). "Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma" (PDF). The Biochemical Journal. 427 (2): 255–264. doi:10.1042/bj20090851. PMID 20102333. S2CID 1043396.

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