Bartolomeo d'Alviano (1455–1515), Italian condottiero and captain, fought in the defense of the Venetian Republic against the Holy Roman Emperor Maximilian
Bartolomeo d'Aragona (fl. late 14th–early 15th centuries), Sicilian nobleman and statesman; defeated in a rebellion and exiled
Bartolomeo degli Organi (1474–1539), Italian composer, singer, and organist of the Renaissance
Bartolomeo Eustachi a.k.a. Eustachius (c. 1500–1574), Italian anatomist, one of the founders of the science of human anatomy, eponym of the Eustachian tube
Bartolomeo Facio (1400–1457), Italian historian, writer, and humanist
Bartolomeo Gastaldi (1818–1879), Italian geologist and paleontologist, one of the founders of the Club Alpino Italiano
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