Professor Carlos Caldas FMedSci is a clinician scientist and Professor of Cancer Medicine at the University of Cambridge . He is the Chair of Cancer Medicine at the University of Cambridge, an Honorary Consultant Medical Oncologist at Addenbrooke's Hospital and Director of the Cambridge Breast Cancer Research Unit.[ 1] [ 2] He is a fellow of Robinson College, Cambridge [ 3] and an Emeritus Senior Investigator at the National Institute for Health Research (NIHR).[ 4]
Professor Carlos Caldas graduated from the University of Lisbon Medical School before training in Internal Medicine in University of Texas Southwestern , Dallas and Medical Oncology at Johns Hopkins Hospital , Baltimore. He then moved to the Institute of Cancer Research , London to complete a research fellowship.[ 1]
Research and career [ edit ]
Caldas' research focuses on the functional genomics of breast cancer .[ 5] [ 6] Caldas led the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) study, analysing the genome and transcriptome of tumours from nearly 2,000 women and comparing this with long-term clinical information including survival, age and diagnosis. The METABRIC study concluded that breast cancer was at least ten different subtypes, characterised by distinct genomic drivers.[ 7] [ 8] In 2019, the team published research showing the subtype a women's breast cancer is initially placed in could predict the likelihood of the tumour returning or metastasising over the next 20 years.[ 9] [ 10] [ 11]
Professor Caldas leads the Personalised Breast Cancer Programme in Cambridge, where woman diagnosed with breast cancer have a sample of their tumour and blood sent for DNA and RNA sequencing . The sequencing results help determine the best course of treatment for patients and can reveal if their tumour is developing resistance to treatment.[ 12] [ 13] [ 14]
^ a b "Prof C Caldas | Cambridge University Hospitals" . www.cuh.nhs.uk . Retrieved 2019-08-29 .
^ kla29@cam.ac.uk. "Professor Carlos Caldas — Department of Oncology" . www.oncology.cam.ac.uk . Retrieved 2019-08-29 . {{cite web }}
: CS1 maint: numeric names: authors list (link )
^ Caldas's Robinson College webpage
^ "NIHR Senior Investigators 2020" . NIHR . Retrieved 2022-02-09 .
^ "Carlos Caldas - Google Scholar Citations" . scholar.google.co.uk . Retrieved 2019-08-29 .
^ "Caldas Group" . Cancer Research UK Cambridge Institute . Retrieved 2019-08-29 .
^ Aparicio, Samuel; Caldas, Carlos; Tavaré, Simon; Brenton, James D.; Børresen-Dale, Anne-Lise; Purushotham, Arnie; Ellis, Ian; Murphy, Leigh; Markowetz, Florian (June 2012). "The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups" . Nature . 486 (7403): 346–352. Bibcode :2012Natur.486..346. . doi :10.1038/nature10983 . ISSN 1476-4687 . PMC 3440846 . PMID 22522925 .
^ Gallagher, James (2012-04-18). "Breast cancer map 'a key moment' " . Retrieved 2019-08-29 .
^ Curtis, Christina; Caldas, Carlos; Aparicio, Samuel; Rueda, Cristina; Pharoah, Paul D.; Ellis, Ian O.; Purushotham, Arnie; Murphy, Leigh; Green, Andrew R. (March 2019). "Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups" . Nature . 567 (7748): 399–404. Bibcode :2019Natur.567..399R . doi :10.1038/s41586-019-1007-8 . ISSN 1476-4687 . PMC 6647838 . PMID 30867590 .
^ Gallagher, James (2019-03-14). "Cancer's 'internal wiring' predicts relapse risk" . Retrieved 2019-08-29 .
^ "Breast cancer test could predict chances of disease's return 20 years later, study shows" . The Independent . 2019-03-13. Retrieved 2019-08-29 .
^ Walsh, Fergus (2018-06-27). "DNA 'barcode' can transform cancer care" . Retrieved 2019-08-29 .
^ Pilgrim, Tom (2018-07-23). "Breast cancer DNA 'barcoding' programme set to expand" . cambridgenews . Retrieved 2019-08-29 .
^ "PBCP study takes breast cancer research to the next level in the development of personalised cancer medicine | Cambridge University Hospitals" . www.cuh.nhs.uk . Retrieved 2019-08-29 .
^ "Professor Carlos Caldas | The Academy of Medical Sciences" . acmedsci.ac.uk . Retrieved 2019-08-29 .
^ "Fellows| European Academy of Cancer Sciences" . www.europeancanceracademy.eu . Archived from the original on 2019-07-04. Retrieved 2019-08-29 .
^ "Find people in the EMBO Communities" . people.embo.org . Retrieved 2019-08-29 .
^ "Three Group Leaders elected to EMBO Membership" . Cancer Research UK Cambridge Institute . 2015-05-20. Retrieved 2019-08-29 .
^ "Press Release: ESMO Recognises Carlos Caldas with Hamilton Fairley Award | ESMO" . www.esmo.org . Retrieved 2019-08-29 .
^ "ESHG Award | ESHG" . www.eshg.org . Retrieved 2021-03-25 .