Glycoside hydrolase families
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There are many characterised protein families with Glycoside hydrolase activity EC 3.2.1.. These enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. Families are defined based on their sequence similarity.[1][2][3] This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.[4] Because the fold of proteins is better conserved than their sequences, some of the families can be grouped into 'clans' (superfamilies). As of October 2011, CAZy includes 128 families of glycosyl hydrolases, grouped into 14 clans.
References
[edit]- ^ Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090–7094. Bibcode:1995PNAS...92.7090H. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375.
- ^ Henrissat B, Davies G (1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–859. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
- ^ Henrissat B, Bairoch A (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". Biochem. J. 316 (2): 695–6. doi:10.1042/bj3160695. PMC 1217404. PMID 8687420.
- ^ Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, Henrissat B (January 2009). "The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics". Nucleic Acids Res. 37 (Database issue): D233–8. doi:10.1093/nar/gkn663. PMC 2686590. PMID 18838391.
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