Deoxyguanosine kinase

See DGUOK for a more thorough description of the human deoxyguanosine kinase.

In enzymology, a deoxyguanosine kinase (EC 2.7.1.113) is an enzyme that catalyzes the chemical reaction

ATP + deoxyguanosine ${\displaystyle \rightleftharpoons }$ ADP + dGMP

Thus, the two substrates of this enzyme are ATP and deoxyguanosine, whereas its two products are ADP and dGMP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:deoxyguanosine 5'-phosphotransferase. Other names in common use include deoxyguanosine kinase (phosphorylating), (dihydroxypropoxymethyl)guanine kinase, 2'-deoxyguanosine kinase, and NTP-deoxyguanosine 5'-phosphotransferase. This enzyme participates in purine metabolism.

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2JAQ, 2JAS, 2JAT, and 2OCP.

Mutations in this gene have been linked to inherited mitochondrial DNA depletion syndromes, neonatal liver failure, nystagmus and hypotonia.

• Barker J, Lewis RA (1981). "Deoxyguanosine kinase of neonatal mouse skin tissue". Biochim. Biophys. Acta. 658 (1): 111–23. doi:10.1016/0005-2744(81)90254-0. PMID 6260206.
• Gower Jr WR, Carr MC, Ives DH (1979). "Deoxyguanosine kinase. Distinct molecular forms in mitochondria and cytosol". J. Biol. Chem. 254 (7): 2180–3. doi:10.1016/S0021-9258(17)30201-6. PMID 218928.