Dioguardi or DioGuardi is a surname. Notable people with the surname include:
- Giovanni Dioguardi, also known as Johnny Dio, (1914–1979), American labor racketeer
- [Randy DioGuardi] (born 1977), Businessman Entrepreneur
- Joe DioGuardi (born 1940), American politician
- Kara DioGuardi (born 1970), American singer-songwriter
- Nick Dioguardi (1932–2015), Italian-born American racing driver
- Pasta Dioguardi, Argentine actor
- Patrizia Dioguardi, Italian-Canadian singer better known as Patrizia