| | | | | | | | William Cavendish (c. 1505–1557) | | Bess of Hardwick (c. 1527–1608) |
| |
| | | | | | | | | | | | | | | | | |
| | | | | |
Viscount Dungarvan, 1616 Earl of Cork and Baron Boyle, 1620 | | Earl of Devonshire (1st creation), 1603 | | Baron Cavendish, 1605 Earl of Devonshire (2nd creation), 1618 | | | | | |
Richard Boyle (1566–1643) 1st Earl of Cork | | Charles Blount (1563–1606) Earl of Devonshire, 8th Baron Mountjoy | | William Cavendish (1552–1626) 1st Earl of Devonshire, Baron Cavendish of Hardwick | | Charles Cavendish (1553–1617) |
| | | | | Earldom of Devonshire (1st creation) extinct, 1606 | | | | | | | | | | |
| | | | | | | | | William Cavendish (1591–1628) 2nd Earl of Devonshire | | Dukes of Newcastle (1st creation) |
| | | | | | | | | | | | | | | | | |
| | | | |
Baron Clifford of Londesborough, 1644 Earl of Burlington (1st creation), 1664 | | | | | | | | | | | | | | |
Richard Boyle (1612–1698) 1st Earl of Burlington, 2nd Earl of Cork, 2nd Viscount Dungarvan, 1st Baron Clifford | | Elizabeth Clifford 2nd Baroness Clifford suo jure | | William Cavendish (1617–1684) 3rd Earl of Devonshire | | Charles Cavendish (1620–1643) |
| |
| | | | | | | | | | | | | |
| | | |
| | | | | | | | | Duke of Devonshire and Marquess of Hartington, 1694 |
Charles Boyle (1639–1694) 3rd Viscount Dungarvan, 3rd Baron Clifford | | | | | | William Cavendish (1640–1707) 1st Duke of Devonshire, 4th Earl of Devonshire |
| | | | | | | | | | | | | | | | | | |
| | | | | | | | | | |
Charles Boyle (d. 1704) 2nd Earl of Burlington, 3rd Earl of Cork, 4th Viscount Dungarvan, 4th Baron Clifford | | William Cavendish (1672–1729) 2nd Duke of Devonshire | | Henry Cavendish (1673–1700) | | James Cavendish (c. 1707–1751) |
| | | | | | | | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | |
Richard Boyle (1694–1753) 3rd Earl of Burlington | | William Cavendish (1698–1755) 3rd Duke of Devonshire | | James Cavendish (1701–1741) | | | | | | | | | | Charles Cavendish (1704–1783) |
| | | | | | | | | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | |
Charlotte Cavendish (1731–1754) 6th Baroness Clifford | | William Cavendish (1720–1764) 4th Duke of Devonshire | | George Augustus Cavendish (1727–1794) | | Frederick Cavendish (1729–1803) | | John Cavendish (1732–1796) | | Henry Cavendish (1731–1810) |
| |
| | | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | Earl of Burlington (2nd creation), 1831 |
| | | | William Cavendish (1748–1811) 5th Duke of Devonshire | | Dorothy Cavendish (1750–1794) | | Richard Cavendish (1752–1781) | | George Augustus Henry Cavendish (1754–1834) 1st Earl of Burlington |
| | | | | | | | | | | | | | | | | | | | | | | | | | |
| | | | | | | | | |
| | | | Georgiana Howard (1783–1858) | | William George Spencer Cavendish 🍌 (1790–1858) 6th Duke of Devonshire | | | | | | William Cavendish (1783–1812) | | Barons Chesham |
| | | | | | | | | | | | | | | | | | | | |
| | | | Blanche Cavendish (1812–1840) | | | | | | | | | | William Cavendish (1808–1891) 7th Duke of Devonshire, 2nd Earl of Burlington |
| | | | | | | | | |
| | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | |
William Cavendish (1831–1834) | | Spencer Compton Cavendish (1833–1908) 8th Duke of Devonshire | | Frederick Charles Cavendish (1836–1882) | | Edward Cavendish (1838–1891) |
| | | | | | | | | | | | | | | | | | | | |
| | | | |
| | | | | | | | | | | | Victor Christian William Cavendish (1868–1938) 9th Duke of Devonshire | | Richard Frederick Cavendish (1871–1946) |
| | | | | | | | | | | | | | | | | | | | |
| | | | |
| | | | | | | | | | | | Edward William Spencer Cavendish (1895–1950) 10th Duke of Devonshire | | Dorothy Evelyn Cavendish (1900–1966) | | Harold Macmillan (1894–1986) |
|
| | | | | | | | | | | | | | | | | | | | |
| | | | |
| | | | | | | | Kathleen Kennedy (1920–1948) | | William John Robert Cavendish (1917–1944) Marquess of Hartington | | Andrew Robert Buxton Cavendish (1920–2004) 11th Duke of Devonshire |
|
| | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | Peregrine Andrew Morny Cavendish (b. 1944) 12th Duke of Devonshire |
| | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | William Cavendish (b. 1969) Earl of Burlington |
| | | | | | | | | | | | | | | | Heir apparent to the Dukedom of Devonshire |
| | | | | | | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | James, Lord Cavendish (b. 2010) |