GJD4

GJD4
Identifiers
Aliases	GJD4, CX40.1, gap junction protein delta 4
External IDs	OMIM: 611922 MGI: 2444990 HomoloGene: 17692 GeneCards: GJD4
Gene location (Human)
Chr.	Chromosome 10 (human)
End	35,608,935 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	9,282,809 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; ventricle; ; left ventricle; ; human musculoskeletal system; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; muscular system; ; muscle organ; ; zone of skin; ; skin of limb;
	Top expressed in
	thoracic diaphragm; ; neural tube; ; autopod region; ; foot; ; hand; ; foregut; ; stomach; ; upper arm; ; thigh;
	More reference expression data
	n/a
Orthologs
	219770
	225152
	ENSG00000177291
	ENSMUSG00000036855
	Q96KN9
	Q8BSD4
	NM_153368
	NM_153086
	NP_699199
	NP_694726
	Wikidata
View/Edit Human	View/Edit Mouse

Gap junction delta-4 protein (GJD4), also known as connexin-40.1 (Cx40.1), is a protein that in humans is encoded by the GJD4 gene.^[5]

Function[edit]

Connexins, such as GJD4, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.^[5]^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177291 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036855 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: gap junction protein".
^ Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038. S2CID 225894.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177291 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036855 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: gap junction protein".

[pmid12881038-6] Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038. S2CID 225894.

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