On 9 November 2021, LFA commissioner Alejandro Jaimes announced a franchise in Tijuana would be joining the Reyes de Jalisco as one of the two expansion teams ahead of the 2022 season.[1][2] The Galgos de Tijuana were established on 17 November, revealing their name, logo and uniforms.[3][4] The project was undertaken in part by Grupo Caliente, owners of Club Tijuana.[5]Guillermo Ruiz Burguete was announced as the first head coach while wide receiver Luis Araujo was their "franchise player".[4] The first tryout was held at the CETYS University [es] Tijuana campus just a few days later, with over 100 player attending.[6] The inaugural roster included 17 players from colleges in Tijuana, three from Ensenada and three from Mexicali.[7]
The Galgos played their first game on 4 March 2022, kicking off the 2022 season against fellow expansion team Gallos Negros de Querétaro at Estadio Caliente with a 9–33 loss. Paul Ortíz kicked a first-quarter field goal for the first points in team history, while Alejandro Meléndez threw the team's first-ever touchdown to Cody Smith in the game's closing minutes.[8][9] Galgos ended the 2022 season with a 0–6 record, becoming the first LFA team to finish a season with no wins.[10]
Ahead of the 2023 LFA season, the Galgos hired Héctor del Águila as their head coach.[11] They also signed former NFL players Trevone Boykin and Terrance Williams.[12][13] The Galgos achieved their first-ever victory in their season opener, beating the Mexicas de la Ciudad de México 24–6.[14] They improved their record to 5–5, earning a playoff berth for the first time in franchise history.[15] The Galgos suffered a 15–3 defeat to the Reyes de Jalisco in the Wild Card game.[16]