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George Weinstock

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George Weinstock
George Weinstock
Born(1949-02-06)6 February 1949
Died26 November 2023(2023-11-26) (aged 74)[1]
Alma materUniversity of Michigan, MIT
Scientific career
InstitutionsJackson Laboratory
The Genome Institute
Washington University School of Medicine
Doctoral advisorDavid Botstein

George M. Weinstock (born February 6, 1949) is an American geneticist and microbiologist on the faculty of The Jackson Laboratory for Genomic Medicine, where he is a professor and the associate director for microbial genomics. Before joining The Jackson Laboratory, he taught at Washington University in St. Louis and served as associate director of The Genome Institute. Previously, Weinstock was co-director of the Human Genome Sequencing Center (HGSC) at Baylor College of Medicine in Houston, Texas, and Professor of Molecular and Human Genetics. He received his B.S. degree from the University of Michigan in 1970 and his Ph.D. from the Massachusetts Institute of Technology in 1977. He has spent most of his career taking genomic approaches to study fundamental biological processes.

Weinstock's parents met during the Manhattan Project in Los Alamos, New Mexico, and he grew up meeting many of the participants in the atomic bomb project and their colleagues. He performed his PhD thesis under David Botstein at MIT, studying the structure of phage P22 chromosome.

As a postdoctoral fellow with I. R. Lehman at Stanford University School of Medicine, Weinstock and Kevin McEntee discovered that the RecA protein of E. coli catalyzed strand transfer in genetic recombination. Later, as a faculty member at the University of Texas Health Science Center at Houston, he led one of the first bacterial genome projects, collaborating with The Institute for Genomic Research to sequence the entire genome of a bacterium, Treponema pallidum, the organism that causes syphilis.[2] In 1999 he joined Richard Gibbs at the HGSC as one of the five main centers to work on the Human Genome Project.[3] The HGSC produced sequences of human chromosomes 3,[4] 12[5] and X.[6] Weinstock was a principal investigator in projects producing genome sequences for rat,[7] mouse,[8] macaque,[9] bovine,[10] sea urchin,[11] honey bee,[12] fruit fly[13] and many microbial genomes, as well as one of the first personal genome projects, sequencing James Watson’s genome using next-generation sequencing technology.[14]

He was a leader of the Human Microbiome Project,[15] studying the collection of microbes that colonize the human body.[16]

Awards and honors

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References

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  1. ^ "In Memorium: George Weinstock PhD" The University of Texas Health Science Center at Houston. 5 December 2023.
  2. ^ "Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete ." Archived 2009-02-10 at the Wayback Machine Science. 17 July 1998.
  3. ^ "Initial sequencing and analysis of the human genome." Archived 2010-10-16 at the Wayback Machine Nature. 15 February 2010; 409, 860-921
  4. ^ "The DNA sequence, annotation and analysis of human chromosome 3." Archived 2010-04-14 at the Wayback Machine Nature. 17 March 2006.
  5. ^ "The finished DNA sequence of human chromosome 12." Archived 2010-04-14 at the Wayback Machine Nature. 31 December 2005.
  6. ^ "The DNA sequence of the human X chromosome." Archived 2012-08-31 at the Wayback Machine Nature. 7 February 2005.
  7. ^ "http://www.nature.com/nature/journal/v428/n6982/full/nature02426.html." Archived 2010-05-31 at the Wayback Machine Nature. 20 February 2004.
  8. ^ "Lineage-Specific Biology Revealed by a Finished Genome Assembly of the Mouse." Archived 2010-08-05 at the Wayback Machine PLoS Biology. 5 May 2009.
  9. ^ "Evolutionary and Biomedical Insights from the Rhesus Macaque Genome." Archived 2009-10-29 at the Wayback Machine Science. 13 April 2007.
  10. ^ "Bos taurus genome assembly." Archived 2012-11-02 at the Wayback Machine BMC Genomics. 24 April 2009.
  11. ^ "The Genome of the Sea Urchin Strongylocentrotus purpuratus." Archived 2010-07-22 at the Wayback Machine Science. 10 November 2006.
  12. ^ "Insights into social insects from the genome of the honeybee Apis mellifera." Archived 2010-12-10 at the Wayback Machine Nature. 26 October 2006.
  13. ^ "The Genome Sequence of Drosophila melanogaster." Archived 2009-04-08 at the Wayback Machine Science. 24 March 2000.
  14. ^ "The $2 Million Genome." Archived 2010-06-19 at the Wayback Machine Technology Review. 1 June 2007.
  15. ^ "How Microbes Defend and Define Us" Archived 2023-08-11 at the Wayback Machine The New York Times. 12 July 2010.
  16. ^ NIH Project Description Archived 2011-07-16 at the Wayback Machine.
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