Glucuronate isomerase
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| glucuronate isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.3.1.12 | ||||||||
| CAS no. | 9023-87-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a glucuronate isomerase (EC 5.3.1.12) is an enzyme that catalyzes the chemical reaction
- D-glucuronate D-fructuronate
Hence, this enzyme has one substrate, D-glucuronate, and one product, D-fructuronate.
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is D-glucuronate aldose-ketose-isomerase. Other names in common use include uronic isomerase, uronate isomerase, D-glucuronate isomerase, uronic acid isomerase, and D-glucuronate ketol-isomerase. This enzyme participates in pentose and glucuronate interconversions.
Structural studies[edit]
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1J5S and 2Q01.
References[edit]
- Ashwell G, Wahba AJ, Hickman J (1960). "Uronic acid metabolism in bacteria. I. Purification and properties of uronic acid isomerase in Escherichia coli". J. Biol. Chem. 235: 1559–1565. PMID 13794771.
- KILGORE WW, STARR MP (1959). "Catabolism of galacturonic and glucuronic acids by Erwinia carotovora". J. Biol. Chem. 234: 2227–35. PMID 14409051.
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