GntR-like bacterial transcription factors

Bacterial regulatory proteins, gntR family
solution structure of streptmycal repressor trar
Identifiers
Symbol	GntR
Pfam	PF00392
Pfam clan	CL0123
InterPro	IPR000524
PROSITE	PDOC00042
SCOP2	1e2x / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, the GntR-like bacterial transcription factors are a family of transcription factors.

Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon.^[1] Family members include GntR, HutC, KorA, NtaR, FadR, ExuR, FarR, DgoR, PhnF and PlmA.^[2]

The crystal structure of the FadR protein has been determined.^[3] In general, these proteins contain a DNA-binding HTH domain at the N-terminus, and an effector-binding or oligomerisation domain at the C-terminus. The DNA-binding domain is well conserved in structure for the whole of the GntR family, consisting of a 3-helical bundle core with a small beta-sheet (wing); the GntR winged helix structure is similar to that found in several other transcriptional regulator families. The regions outside the DNA-binding domain are more variable and are consequently used to define GntR subfamilies.^[4]