HOTHEAD (gene)

HOTHEAD is an Arabidopsis thaliana gene that encodes a flavin adenine dinucleotide-containing oxidoreductase. This gene has a role in the creation of the carpel during the formation of flowers through the fusion of epidermal cells.^[1] Observations of reversion of the hothead phenotype and genotype led to the suggestion that the plants were able to "remember" the sequences of genes present in their ancestors, possibly through a cache of complementary RNA.^[2] This report attracted broad attention,^[3] and alternative explanations were suggested.^[4]^[5]^[6] Later research suggested that the supposed reversion phenomenon was due to the plants having a pronounced bias towards outcrossing (because of their floral defects), rather than self-fertilizing at high rates, as is typical for A. thaliana.^[7]^[8]^[9]^[10]

References

^ Krolikowski KA, Victor JL, Wagler TN, Lolle SJ, Pruitt RE (August 2003). "Isolation and characterization of the Arabidopsis organ fusion gene HOTHEAD". Plant J. 35 (4): 501–11. doi:10.1046/j.1365-313x.2003.01824.x. PMID 12904212.
^ Lolle SJ, Victor JL, Young JM, Pruitt RE (March 2005). "Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis". Nature. 434 (7032): 505–9. Bibcode:2005Natur.434..505L. doi:10.1038/nature03380. PMID 15785770. S2CID 1352368.
^ Wade, Nicholas (2005-03-23). "Startling scientists, plant fixes its flawed gene". The New York Times. ISSN 0362-4331. Retrieved 2016-10-24.
^ Chaudhury, A. (2005). "Hothead healer and extragenomic information". Nature. 437 (7055): E1–E2. Bibcode:2005Natur.437E...1C. doi:10.1038/nature04062. PMID 16136082.
^ Comai L, Cartwright RA (2005). "A toxic mutator and selection alternative to the non-Mendelian RNA cache hypothesis for hothead reversion". Plant Cell. 17 (11): 2856–8. doi:10.1105/tpc.105.036293. PMC 1276014. PMID 16267378. summary Archived 2013-06-21 at the Wayback Machine
^ Krishnaswamy L and Peterson T (2006). "An Alternate Hypothesis to explain the high frequency of "revertants" in Hothead mutants in Arabidopsis". Plant Biology. 9 (1): 30–1. doi:10.1055/s-2006-924563. PMID 17048144.
^ Peng P, Chan SW, Shah GA, Jacobsen SE (September 2006). "Plant genetics: increased outcrossing in hothead mutants". Nature. 443 (7110): E8, discussion E8–9. Bibcode:2006Natur.443E...8P. doi:10.1038/nature05251. PMID 17006468.
^ Lolle S. J.; et al. (2006). "Increased outcrossing in hothead mutants (Reply)". Nature. 443 (7110): E8–E9. Bibcode:2006Natur.443E...8L. doi:10.1038/nature05252. S2CID 4425565.
^ Pennisi E (2006). "Genetics. Pollen contamination may explain controversial inheritance". Science. 313 (5795): 1864. doi:10.1126/science.313.5795.1864. PMID 17008492. S2CID 82215542.
^ Mercier R, Jolivet S, Vignard J, et al. (December 2008). "Outcrossing as an explanation of the apparent unconventional genetic behavior of Arabidopsis thaliana hth mutants". Genetics. 180 (4): 2295–7. doi:10.1534/genetics.108.095208. PMC 2600959. PMID 18845842.

External links and further reading

Recommendations of 2005 paper on F1000 (most rated paper in the history of the site): http://f1000.com/prime/1024824
Post by Ogden (2013) describing a follow-up paper: http://blog.f1000research.com/2013/02/04/meddling-with-mendel/
News piece by Gawrylewski (2008): http://www.the-scientist.com/?articles.view/articleNo/26000/title/Mendel-upended-/
HOTHEAD locus page: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=30300

[1] Krolikowski KA, Victor JL, Wagler TN, Lolle SJ, Pruitt RE (August 2003). "Isolation and characterization of the Arabidopsis organ fusion gene HOTHEAD". Plant J. 35 (4): 501–11. doi:10.1046/j.1365-313x.2003.01824.x. PMID 12904212.

[2] Lolle SJ, Victor JL, Young JM, Pruitt RE (March 2005). "Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis". Nature. 434 (7032): 505–9. Bibcode:2005Natur.434..505L. doi:10.1038/nature03380. PMID 15785770. S2CID 1352368.

[3] Wade, Nicholas (2005-03-23). "Startling scientists, plant fixes its flawed gene". The New York Times. ISSN 0362-4331. Retrieved 2016-10-24.

[4] Chaudhury, A. (2005). "Hothead healer and extragenomic information". Nature. 437 (7055): E1–E2. Bibcode:2005Natur.437E...1C. doi:10.1038/nature04062. PMID 16136082.

[5] Comai L, Cartwright RA (2005). "A toxic mutator and selection alternative to the non-Mendelian RNA cache hypothesis for hothead reversion". Plant Cell. 17 (11): 2856–8. doi:10.1105/tpc.105.036293. PMC 1276014. PMID 16267378. summary Archived 2013-06-21 at the Wayback Machine

[6] Krishnaswamy L and Peterson T (2006). "An Alternate Hypothesis to explain the high frequency of "revertants" in Hothead mutants in Arabidopsis". Plant Biology. 9 (1): 30–1. doi:10.1055/s-2006-924563. PMID 17048144.

[7] Peng P, Chan SW, Shah GA, Jacobsen SE (September 2006). "Plant genetics: increased outcrossing in hothead mutants". Nature. 443 (7110): E8, discussion E8–9. Bibcode:2006Natur.443E...8P. doi:10.1038/nature05251. PMID 17006468.

[8] Lolle S. J.; et al. (2006). "Increased outcrossing in hothead mutants (Reply)". Nature. 443 (7110): E8–E9. Bibcode:2006Natur.443E...8L. doi:10.1038/nature05252. S2CID 4425565.

[9] Pennisi E (2006). "Genetics. Pollen contamination may explain controversial inheritance". Science. 313 (5795): 1864. doi:10.1126/science.313.5795.1864. PMID 17008492. S2CID 82215542.

[10] Mercier R, Jolivet S, Vignard J, et al. (December 2008). "Outcrossing as an explanation of the apparent unconventional genetic behavior of Arabidopsis thaliana hth mutants". Genetics. 180 (4): 2295–7. doi:10.1534/genetics.108.095208. PMC 2600959. PMID 18845842.

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