The pizzeria was located on Killingsworth Street in northeast Portland's Vernon neighborhood and shared a space with Seastar Bakery.[1][2] Handsome's pizzas were "New York-Neapolitan hybrids" and featured sourdough crusts, baked in a custom-built, wood-fired oven.[3]
Will Fain acquired the Pizza Depokos cart in 2011[4] and rebranded the business as Handsome Pizza in 2012.[5] The restaurant operated from a garage in north Portland, until relocating to Killingsworth in August 2015.[3][2][6] During a gap between the two locations, Handsome hosted a series of pop-ups at the bakery Tabor Bread.[7][8] In 2020, fifteen employees were laid off because of the impact of the COVID-19 pandemic.[9] In 2022, owners announced plans to close on August 14.[10][11][12] The pizzeria No Saint moved into the space.[13]
Michael Russell included Handsome in The Oregonian's 2016 list of Portland's best new restaurants.[14] The newspaper's Samantha Bakall included the pizzeria in a list of Portland's best wood-fired pizza.[15] In 2018, Russell ranked Handsome number five in a list of Portland's top ten pizzerias,[16] and number six in a list of the city's best pizza by the slice.[17] In 2021, Brooke Jackson-Glidden included Handsome in Eater Portland's overview of eateries for "exceptional" pizzas in the city and said the "hyper-seasonal specials are often stunners".[18]