Ciano began with the filming of the Horror-Action film in October 2010.[5]Michael Madsen, Christy Carlson Romano and William Forsythe were cast as the leads of the film.[6] The Woodhaven Production Company produced the film.[7] Glenn Ciano co-wrote the script with Robert Rotondo Jr., but the story was originally an idea of Ciano's.[8] The film was produced by director Glenn Ciano. It was filmed on location in Foster, Rhode Island.
The original release was set for the late 2010.[9] The film premiered at Worcester's 2012 Rock and Shock Convention[10] and was released onto DVD on April 9, 2013.[11]
John Townsend, writing for "HorrorNews.net" said, "The characters are blatant stereotypes, there is an alarming amount of soft focus used, the gory sections just aren’t convincing and some scenes are just in poor taste. It is as if the filmmakers weren’t sure quite what type of film they wanted to make; there is a bit of exploitation, a hint to survival horror, a pinch of a splatter movie, and what they have delivered is, to put as simply as possible, a mess."[12]
Naila Scargill, writing for "Exquisite Terror" said, "Initially amusing due to a self-conscious, rather deliberate campiness, Infection Z rapidly dulls."[13]
A review at Moirareviews praised the first part and its scenario and acting but lamented the film's lack of originality and directing in the end.[14]