He was the son and heir of William Cheyne (d. 1441) and Margaret, daughter and heir of Sir Robert de Shurland.[1]
In around 1439 he married Eleanor, daughter of Sir Robert Shottesbrooke of Faringdon, Berkshire, by whom he had nine sons, including:[2]
William Cheyne (d. 1487), married firstly, Isabel Boleyn, daughter of Sir Geoffrey Boleyn, by whom he had a son, Sir Francis Cheyne and secondly, Margaret Young, by whom he had a son, Sir Thomas Cheyne.