L1TD1

L1TD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LR6, 3SOO
Identifiers
Aliases	L1TD1, ECAT11, LINE-1 type transposase domain containing 1, LINE1 type transposase domain containing 1
External IDs	MGI: 3578435; HomoloGene: 136289; GeneCards: L1TD1; OMA:L1TD1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 62,194,849 bp[1] End 62,212,328 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C6 Start 98,614,971 bp[2] End 98,626,717 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle placenta appendix mucosa of transverse colon white blood cell monocyte right testis left testis epithelium of colon Top expressed in yolk sac epiblast embryo blastocyst blastocyst primitive streak morula embryo tail of embryo hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function single-stranded RNA binding protein binding Cellular component ribonucleoprotein complex Biological process transposition, RNA-mediated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54596 381591 Ensembl ENSG00000240563 ENSMUSG00000087166 UniProt Q5T7N2 Q587J6 RefSeq (mRNA) NM_019079 NM_001164835 NM_001081202 RefSeq (protein) NP_001158307 NP_061952 NP_001074671 Location (UCSC) Chr 1: 62.19 – 62.21 Mb Chr 4: 98.61 – 98.63 Mb PubMed search [3] [4]
Wikidata
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LINE-1 type transposase domain containing 1, also known as L1TD1, is an RNA-binding protein that involved with self-renewal of undifferentiated human embryonic stem cells and cancer cell proliferation. L1TD1 has been reported to associate with the development of several cancers. ^{[5] [6] [7] [8]}