This is a list of the top-level leaders for religious groups with at least 50,000 adherents, and that led anytime from January 1, 1301, to December 31, 1400. It should likewise only name leaders listed on other articles and lists.
- Boniface VIII, Pope (1294–1303)
- Benedict XI, Pope (1303–1304)
- Clement V, Pope (1305–1314)
- John XXII, Pope (1316–1334)
- Benedict XII, Pope (1334–1342)
- Clement VI, Pope (1342–1352)
- Innocent VI, Pope (1352–1362)
- Urban V, Pope (1362–1370)
- Gregory XI, Pope (1370–1378)
- Urban VI, Pope (1378–1389)
- Boniface IX, Pope (1389–1404)
- John XII, Ecumenical Patriarch of Constantinople (1294–1303)
- Athanasius I, Ecumenical Patriarch of Constantinople (1289–1293, 1303–1310)
- Nephon I, Ecumenical Patriarch of Constantinople (1310–1314)
- John XIII Glykys, Ecumenical Patriarch of Constantinople (1315–1320)
- Gerasimos I, Ecumenical Patriarch of Constantinople (1320–1321)
- Isaias, Ecumenical Patriarch of Constantinople (1323–1334)
- John XIV Kalekas, Ecumenical Patriarch of Constantinople (1334–1347)
- Isidore I, Ecumenical Patriarch of Constantinople (1347–1350)
- Callistus I, Ecumenical Patriarch of Constantinople (1350–1354, 1355–1363)
- Philotheus Kokkinos, Ecumenical Patriarch of Constantinople (1354–1355, 1364–1376)
- Callistus I, Ecumenical Patriarch of Constantinople (1350–1354, 1355–1363)
- Philotheus Kokkinos, Ecumenical Patriarch of Constantinople (1354–1355, 1364–1376)
- Macarius, Ecumenical Patriarch of Constantinople (1376–1379, 1390–1391)
- Nilus Kerameus, Ecumenical Patriarch of Constantinople (1379–1388)
- Antony IV, Ecumenical Patriarch of Constantinople (1389–1390, 1391–1397)
- Macarius, Ecumenical Patriarch of Constantinople (1376–1379, 1390–1391)
- Antony IV, Ecumenical Patriarch of Constantinople (1389–1390, 1391–1397)
- Callistus II Xanthopoulos, Ecumenical Patriarch of Constantinople (1397)
- Matthew I, Ecumenical Patriarch of Constantinople (1397–1410)
- al-Hakim I, Caliph (1262–1302)
- al-Mustakfi I, Caliph (1303–1340)
- al-Wathiq I, Caliph (1340–1341)
- al-Hakim II, Caliph (1341–1352)
- al-Mu'tadid I, Caliph (1352–1362)
- al-Mutawakkil I, Caliph (1362–1377, 1377–1383, 1389–1406)
- al-Musta'sim, Caliph (1377, 1386–1389)
- al-Wathiq II, Caliph (1383–1386)
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- Ala al-Din Mu'min Shah ibn Muhammad
- Muhammad Shah ibn Mu'min Shah
- Radhi al-Din ibn Muhammad Shah