This is a list of the top-level leaders for religious groups with at least 50,000 adherents, and that led anytime from January 1, 401, to December 31, 500. It should likewise only name leaders listed on other articles and lists.
Chalcedonian Christianity
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- Anastasius I, Pope (399–401)
- Innocent I, Pope (401–417)
- Zosimus, Pope (417–418)
- Boniface I, Pope (418–422)
- Celestine I, Pope (422–432)
- Sixtus III, Pope (432–440)
- Leo I the Great, Pope (440–461)
- Hilarius, Pope (461–468)
- Simplicius, Pope (468–483)
- Felix III, Pope (483–492)
- Gelasius I, Pope (492–496)
- Anastasius II, Pope (496–498)
- Symmachus, Pope (498–514)
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- As recognized by Chalcedonian Christianity
- Dioscorus I, Patriarch of Alexandria (444–451; deposed by Chalcedon)
- Proterius, Patriarch of Alexandria (451–457)
- Timothy II Aelurus, Patriarch of Alexandria (457–460, 475–477)
- Timothy III Salophakiolos, Patriarch of Alexandria (460–475, 477–481)
- Timothy II Aelurus, Patriarch of Alexandria (457–460, 475–477)
- Peter III Mongus, Patriarch of Alexandria (477, 482–490)
- Timothy III Salophakiolos, Patriarch of Alexandria (460–475, 477–481)
- John I Talaias, Patriarch of Alexandria (481–482)
- Peter III Mongus, Patriarch of Alexandria (477, 482–490)
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- As recognized by Coptic Christianity
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- Flavian I, Patriarch of Antioch (399–404)
- Porphyrus, Patriarch of Antioch (404–412)
- Alexander, Patriarch of Antioch (412–417)
- Theodotus, Patriarch of Antioch (417–428)
- John I, Patriarch of Antioch (428–442)
- Domnus II, Patriarch of Antioch (442–449) – deposed at Ephesus II
- Maximus, Patriarch of Antioch (449–455)
- Basil of Antioch, Patriarch of Antioch (456–458)
- Acacius of Antioch, Patriarch of Antioch (458–461)
- Martyrius, Patriarch of Antioch (461–469)
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