Austin Peay State University is a public university in Clarksville, Tennessee. The university was called the Austin Peay Normal School from 1925 to 1943 and Austin Peay State College from 1943 to 1967
- Steve Adams, 39th Tennessee State Treasurer
- Andre Barnett, presidential candidate of the Reform Party in the 2012 United States presidential election
- David Bibb, Deputy Administrator of the U.S. General Services Administration[3]
- Riley Darnell, Tennessee State Senator and Tennessee Secretary of State[3]
- Tommy Head, 1967, Tennessee House of Representatives[4]
- Jason Hodges, Tennessee House of Representatives[5]
- Douglas S. Jackson, Tennessee State Senator[6]
- Darren Jernigan, Tennessee House of Representatives[7]
- Curtis Johnson, Tennessee House of Representatives[8]
- Ron Lollar, Tennessee House of Representatives[9]
- John G. Morgan, 1973, Comptroller of the Treasury of Tennessee and Chancellor of the Tennessee Board of Regents[2]
- Joe Pitts, 1980, Mayor of Clarksville, Tennessee and member of the Tennessee House of Representatives[10]
- Jay Reedy, 1990, Tennessee House of Representatives[11]
- Phil Roe, 1967, U.S. House of Representatives[12][2]
- Eric Stewart, Tennessee Sentate[13]
- Eli Abaev, professional basketball player for Hapoel Be'er Sheva in the Israeli Basketball Premier League
- Natalia Ariza, professional soccer player and member of the Colombia women's national football team at the 2012 Summer Olympics
- Tatiana Ariza, professional soccer player and member of the Colombia women's national football team at the 2012 Summer Olympics
- Erik Barnes, professional golfer
- Jack Bushofsky, college football coach and executive
- Rick Christophel, college and professional football coach
- Carrie Daniels, college basketball coach
- TyShwan Edmondson, professional basketball player
- A. J. Ellis, 1993, professional baseball player and special assistant to the general manager for the San Diego Padres[2]
- George Fisher, college basketball coach and athletic administrator
- Calvin Garrett, professional basketball player
- Corey Gipson, college basketball coach
- Jeff Gooch, 1996, professional football players with the Tampa Bay Buccaneers and the Detroit Lions[2]
- Ryne Harper, 2007, professional baseball player[2]
- Trenton Hassell, 2001, professional basketball player, New Jersey Nets[2]
- Will Hogue, World Long Drive competitor and three-time winner
- Chris Horton, professional basketball player for Hapoel Tel Aviv of the Israeli Basketball Premier League
- Otis Howard, professional basketball player, Milwaukee Bucks and Detroit Pistons
- Percy Howard, 1973, professional football player with the Dallas Cowboys[2]
- Shawn Kelley, 2007, professional baseball player with the San Diego Padres[2]
- Braden Layer, college football coach
- Hod Lisenbee, professional baseball player with the Washington Senators, Boston Red Sox, Philadelphia Athletics, and Cincinnati Reds.
- Kristen Mattio, college basketball coach
- Gary McClure, college baseball coach
- Andy McCollum, college football coach
- D. J. Montgomery, professional football player
- Kyran Moore, professional gridiron football player with the Canadian Football League
- Noel Phillips, professional tennis player
- Drake Reed, professional basketball player
- Matt Reynolds, 2007, professional baseball player with the San Francisco Giants[2]
- Josh Robinson, professional basketball players
- Tyler Rogers, 2013, professional baseball player with the San Francisco Giants[2]
- Jared Savage, professional basketball player
- George Sherrill, 1999, professional basebalal player with the Seattle Mariners, the Baltimore Orioles, and the Los Angeles Dodgers[2]
- Bonnie Sloan, 1973, professional football player[2]
- Jimmy Stewart, 1961, professional baseball player and utility man and scout for Major League Baseball[2]
- Barry Sumpter, professional baseball player
- Michael Swift, 1997, professional football player[2]
- Terry Taylor, professional basketball player for the Chicago Bulls
- Greg Tubbs, professional baseball player
- Jamie Walker, 1992, a professional baseball player with the Kansas City Royals, the Detroit Tigers, and the Baltimore Orioles[2]
- Bubba Wells, 1997, professional basketball player with the Dallas Mavericks[2]
- Walt Wells, college football coach
- James "Fly" Williams, professional basketball players
- Howie Wright, professional basketball players
- Jack Zduriencik, former general manager of the Seattle Mariners