Year[a]
|
Event
|
Type
|
Death toll
|
Location
|
Sources
|
1918
|
Spanish flu pandemic
|
Disease
|
28,870
|
Statewide
|
[1]
|
2020
|
COVID-19 pandemic
|
Disease
|
20,872
|
Statewide
|
[2]
|
1693
|
1693 Boston yellow fever epidemic
|
Disease
|
3,100+
|
Boston
|
[3]
|
1911
|
1911 Eastern North America heat wave
|
Weather
|
1,110
|
Statewide
|
[4]
|
1633
|
Massachusetts smallpox epidemic
|
Disease
|
1,000
|
Statewide
|
[5]
|
1721
|
1721 Boston smallpox outbreak
|
Disease
|
844
|
Boston
|
[6]
|
1677
|
1677–1678 Boston smallpox epidemic
|
Disease
|
750–1,000
|
Boston
|
[7]
|
1942
|
Cocoanut Grove fire
|
Fire
|
492
|
Boston
|
[8][9]
|
1898
|
Sinking of the Portland
|
Shipwreck
|
193 to 245
|
off Gloucester[b]
|
[10]
|
1874
|
Mill River Flood of 1874
|
Flood
|
139
|
Williamsburg/Northampton
|
[11]
|
1963
|
Sinking of the USS Thresher
|
Shipwreck
|
129
|
off Cape Cod[c]
|
[12]
|
1884
|
Sinking of the SS City of Columbus
|
Shipwreck
|
103
|
off Martha's Vineyard[d]
|
[13]
|
1953
|
1953 Worcester tornado
|
Weather
|
94
|
Worcester
|
[14]
|
1973
|
Delta Air Lines Flight 723
|
Aviation accident
|
89
|
Boston
|
[15][16]
|
1860
|
Pemberton Mill collapse
|
Collapse (building)
|
88 to 145
|
Lawrence
|
[17][18]
|
1938
|
1938 New England hurricane
|
Weather
|
88
|
Statewide
|
[19]
|
1875
|
Precious Blood Church fire
|
Fire
|
78
|
Holyoke
|
[20]
|
1960
|
Eastern Air Lines Flight 375
|
Aviation accident
|
62
|
Boston Harbor
|
[21][22]
|
1905
|
Grover Shoe Factory disaster
|
Explosion
|
58
|
Brockton
|
[23]
|
1916
|
Summer Street Bridge disaster
|
Railway accident
|
46
|
Boston
|
[24]
|
1956
|
Sinking of the SS Andrea Doria
|
Ship collision
|
46
|
off Nantucket[e]
|
[25]
|
1925
|
Pickwick Club collapse
|
Collapse (building)
|
44
|
Boston
|
[26]
|
1927
|
Sinking of the USS S-4
|
Ship collision
|
40
|
off Provincetown[f]
|
[29]
|
1887
|
Forest Hills disaster
|
Collapse (rail bridge)
|
38
|
Boston
|
[30]
|
1911
|
Septic sore throat outbreak
|
Disease
|
38
|
Boston
|
[31]
|
1953
|
Explosion aboard USS Leyte
|
Shipboard explosion
|
37
|
Boston (Naval Annex)
|
[32][33]
|
1871
|
Great Revere train wreck of 1871
|
Railway collision
|
30
|
Revere
|
[34]
|
1913
|
Arcadia Hotel fire
|
Fire
|
28
|
Boston
|
[35][36]
|
1872
|
Great Boston Fire of 1872
|
Fire
|
26 to 30
|
Boston
|
[37][38]
|
1946
|
Mount Tom B-17 crash
|
Aviation accident
|
25
|
Holyoke
|
[39][40]
|
1874
|
Granite Mill fire
|
Fire
|
23
|
Fall River
|
[41]
|
1890
|
1890 Quincy train wreck
|
Railway accident
|
23
|
Quincy
|
[42]
|
1958
|
Northeast Airlines Flight 258
|
Aviation accident
|
23
|
Nantucket
|
[43][44]
|
1903
|
United States Cartridge Company explosion
|
Explosion
|
22
|
Lowell
|
[45]
|
1915
|
St. John's School fire
|
Fire
|
21
|
Peabody
|
[46]
|
1919
|
Great Molasses Flood
|
Flood
|
21
|
Boston
|
[47]
|
1928
|
Preble Box Toe Company explosion
|
Explosion
|
20
|
Lynn
|
[48]
|
1878
|
Wollaston disaster
|
Railway accident
|
19
|
Quincy
|
[49]
|
1908
|
Great Chelsea fire of 1908
|
Fire
|
19
|
Chelsea
|
[50]
|
1945
|
SS Silver Star Park and SS Mangore collision
|
Ship collision
|
19
|
off New Bedford[g]
|
[53][54]
|
1966
|
1966 Nantucket radar plane crash
|
Aviation accident
|
19
|
off Nantucket[h]
|
[55][56]
|
2012
|
2012–2013 flu season
|
Disease
|
18
|
Statewide
|
[57]
|
1905
|
Baker Bridge train wreck
|
Railway collision
|
17
|
Lincoln
|
[58]
|
1910
|
Morewood Lake Ice Company explosion
|
Explosion
|
17
|
Pittsfield
|
[59]
|
1944
|
Sinking of the USS YF-415
|
Shipboard explosion
|
17
|
off Hingham[i]
|
[60]
|
1804
|
1804 New England hurricane
|
Weather
|
16
|
Statewide
|
[61]
|
1965
|
1965 Nantucket radar plane crash
|
Aviation accident
|
16
|
off Nantucket[j]
|
[62][63]
|
1942
|
Garnet Peak C-53 crash
|
Aviation accident
|
16
|
Peru
|
[64][65]
|
1958
|
Westover Air Force Base KC-135 crash
|
Aviation accident
|
15
|
Chicopee
|
[66][67]
|
1967
|
1967 Nantucket radar plane crash
|
Aviation accident
|
15
|
off Nantucket[k]
|
[68][69]
|
1984
|
Beverly rooming house fire
|
Fire (arson)
|
15
|
Beverly
|
[70]
|
1893
|
Chester train wreck
|
Collapse (rail bridge)
|
14
|
Chester
|
[71]
|
1928
|
Beacon Oil explosion
|
Explosion
|
14
|
Everett
|
[72]
|
1867
|
Hoosac Tunnel Central Shaft accident
|
Collapse (rail tunnel)
|
13
|
Florida
|
[73]
|
1906
|
Amsden Building collapse
|
Collapse (building)
|
13
|
Framingham
|
[74][75]
|
1941
|
Strand Theatre fire
|
Fire
|
13
|
Brockton
|
[76]
|
1942
|
Melvin Hall fire
|
Fire
|
13
|
Lynn
|
[77]
|
1956
|
Swampscott train wreck
|
Railway collision
|
13
|
Swampscott
|
[78]
|
1966
|
Everett train-truck crash
|
Railway accident
|
13
|
Everett
|
[79]
|
1890
|
North End tenement fire (North Street)
|
Fire
|
12
|
Boston
|
[80][81]
|
1952
|
Camp Edwards C-47/F-94B collision
|
Aviation accident
|
12
|
Mashpee
|
[82][83]
|
1958
|
Northeast Airlines Flight 285
|
Aviation accident
|
12
|
New Bedford
|
[84][85]
|
1886
|
Deerfield railway accident
|
Railway accident
|
11
|
Deerfield
|
[86]
|
1902
|
Frank A. Palmer and Louise B. Crary collision
|
Ship collision
|
11
|
off Gloucester[l]
|
[87]
|
1913
|
Lawrence bathhouse tragedy
|
Drowning
|
11
|
Lawrence
|
[88]
|
1919
|
Springfield Boys' Club Camp drownings
|
Drowning
|
11
|
East Otis
|
[89]
|
1964
|
January 1964 blizzard
|
Weather
|
11
|
Statewide
|
[90]
|
1966
|
Paramount Hotel explosion
|
Explosion
|
11
|
Boston
|
[91]
|
1902
|
North End lodging house fire (Fleet Street)
|
Fire
|
10
|
Boston
|
[92][93]
|
1944
|
Mount Holyoke B-24 crash
|
Aviation accident
|
10
|
South Hadley
|
[94][95]
|
1973
|
Worcester rooming house fire
|
Fire
|
10
|
Worcester
|
[96]
|