- Manel Abeysekera, Sri Lanka's first woman diplomat
- Margery Abrahams, first chairperson of the British Dietetic Association
- Ruth Adler, Scotland's first Amnesty International employee
- Caroline Alexander, first woman to publish a full-length English translation of Homer's Iliad
- Rachel Armitage, first New Zealand woman BA to complete a degree at Oxford
- Bolanle Awe, first female academic staff in a Nigerian university and first chairperson of the National Commission for Women (Nigeria)
- Margaret Ballinger, first President of the Liberal Party of South Africa
- Carys Bannister, first female neurosurgeon in the United Kingdom
- Farah Bhatti, first British woman of Pakistani origins to be made a cardiac surgeon in the United Kingdom; first Muslim on the council of the Royal College of Surgeons of England Women in Surgery Forum
- Kalpana Bista, first female Minister of Education, Science and Technology of Nepal
- Susanne Bobzien, first woman to be appointed a tutorial fellow at The Queen's College, Oxford
- Lalage Bown, first organizing secretary of the International Congress of Africanists, first woman to receive the William Pearson Tolley Award from Syracuse University
- Victoria Braithwaite, first person to demonstrate that fish feel pain
- Averil Cameron, first female Warden of Keble College
- Hilda Cashmore (1876-1943), first warden of Barton Hill Settlement in Bristol
- Gwendolen M. Carter, first female president of the African Studies Association
- Margaret Casely-Hayford, first female Chancellor of Coventry University, first black woman to be Partner in a City law firm
- Ethel Charles, first woman to be admitted to the Royal Institute of British Architects and, with her sister Bessie, the first woman to study architecture at University College London
- Maude Clarke, first female to join Queen's University Belfast’s academic staff
- Thérèse Coffey, first female MP for Suffolk Coastal
- Susan Cooper, first woman to edit the Oxford undergraduate newspaper Cherwell
- Maria Czaplicka, first woman to receive a Mianowski Scholarship and first female lecturer in anthropology at Oxford
- Ann Dally, first woman to study medicine at St Thomas' Hospital
- Helen Darbishire, first woman to be chair of the faculty board of English at Oxford
- Elsbeth Dimsdale, first woman to receive a college fellowship at the University of Cambridge
- Barbara Freire-Marreco, one of the first two women to gain a Diploma in Anthropology at Oxford
- Geraldine Penrose Fitzgerald, arguably the first Catholic Oxford woman student
- Kathleen Fitzpatrick, first associate professor in Australia outside the natural sciences
- Fiona Freckleton, won Great Britain's first medal in a major World Championship women's rowing event
- Maggie Gee, first female Chair of the Royal Society of Literature (RSL)
- Jean Ginsburg, first woman to graduate from St Mary's Hospital Medical School
- Rose Graham, first female President of the British Archaeological Association
- Gertrud Herzog-Hauser, first Austrian woman to gain a habilitation at university and Vienna’s first university lecturer in classical languages
- Agnes Headlam-Morley, first woman to be appointed to a chair at Oxford
- Sheila Hill, first woman to be elected to the general council of the Association of Cricket Umpires and Scorers and one of the first ten women granted honorary MCC membership
- Carole Hillenbrand, first non-Muslim to be awarded the King Faisal International Prize for Islamic Studies
- Margaret Hills, first female councillor on Stroud District Council
- Dorothy Hodgkin, also the first woman to receive maternity pay at Oxford and first female Chancellor of the University of Bristol
- Rosalind Hursthouse, first woman to teach at an all men's college in Oxford
- Evelyn Irons, first female war correspondent to be decorated with the French Croix de Guerre, first journalist to reach certain WWII war zones and first female Stanhope Medal recipient
- Peggy Jackson, first female Archdeacon of Llandaff
- Diana Josephson, first woman to lead the National Oceanic and Atmospheric Administration (NOAA) and first female Under Secretary of Commerce for Oceans and Atmosphere
- Mary Keegan, first female audit partner at PwC
- Kathleen Kenyon, first female president of the Oxford University Archaeological Society
- Doris Ketelbey, first woman historian to hold a long-term position at the University of St Andrews
- Laeticia Kikonyogo, first Ugandan woman to be appointed High Court judge and Chief Magistrate
- Alix Kilroy, one of the first two women to have entered the administrative grade of the Civil Service by examination
- Akua Kuenyehia, first First Vice-president of the ICC and Ghana's first female law professor
- Christine Lee, first female scholar of the Oxford University Medical School
- Nemone Lethbridge, first female at Hare Court and one of Britain's first female barristers
- Leah L'Estrange Malone, first female chair of the Jewish Labour Movement
- Genevieve Lloyd, first female professor of philosophy in Australia
- Hilda Lorimer, one of the first three women to participate in an excavation conducted by the British School at Athens
- Leah Lowenstein, first woman dean of a co-education medical school in the United States
- Margaret Mackworth, 2nd Viscountess Rhondda, first female director of the Institute of Directors
- Dorothea Maude, first woman general practitioner in Oxford
- Elizabeth Monk, one of the first two women admitted to the Quebec Bar, first Quebec woman to receive a Queen's Counsel designation, and first woman to receive the Elizabeth Torrance Medal at McGill University
- Michele Moody-Adams, first woman and the first African-American dean at Columbia University.
- Anne Mueller, first female Permanent secretary at HM Treasury
- Isobel Munro, first married Fellow at Oxford
- Hilda D. Oakeley, first Warden of the new Royal Victoria College and first woman to deliver McGill's annual university lecture
- Onora O'Neill, Baroness O'Neill of Bengarve, first female winner of the Berggruen Prize
- Daphne Park, Baroness Park of Monmouth, the highest ranking female officer of her time in the British intelligence services (the Queen of Spies)
- Inez Pearn, first woman to be awarded the de Osma studentship (for research in Spain) at Oxford
- Emily Penrose, first woman to gain a First in Greats (Classics) at Oxford
- Adelaide Plumptre, first woman elected chair of the Canadian Red Cross, TBE and first woman to sit in the Toronto Board of Control
- Mildred Pope, first woman to hold a readership at Oxford
- Lucy Powell, Manchester's first female Labour member of parliament
- Evelyn Procter, first female scholar to be admitted to the National Historical Archive of Spain and the Biblioteca Nacional de España
- Esther Rantzen, first woman to receive a Dimbleby Award from BAFTA
- Elizabeth Anne Reid, world's first advisor on women's affairs to a head of government
- Joyce Reynolds, first woman awarded the Kenyon Medal
- Katherine Routledge, initiated the first true survey of Easter Island
- Diana Rowntree, first architectural writer for The Guardian
- Susan M. Scott, first female physicist to win the Prime Minister's Prizes for Science
- Margaret Seward, first Oxford female student to be entered for the honour school of Mathematics, one of the first two women students at Oxford studying chemistry, earliest Chemist on staff at the Royal Holloway (of which she was a founding Lecturer) and pioneer woman to obtain a first class in the honour school of Natural Science
- Lucy Sichone, first Zambian woman to receive a Rhodes Scholarship and first woman to have her portrait displayed on the walls of the prestigious Rhodes House
- Angela Sinclair-Loutit, first female member of the Friends' Ambulance Unit
- Premala Sivaprakasapillai Sivasegaram, first female engineer in Sri Lanka
- Mary Somerville, first woman controller of a BBC division; first director of BBC School Radio
- May Staveley, first warden of Clifton Hill House, Bristol's women's university settlement
- Theresa Stewart, first female leader of Birmingham City Council
- Lucy Sutherland, first woman undergraduate to speak at the Oxford Union and first female Pro-vice-chancellor of Oxford
- Ann Gaynor Taylor, first female Fellow of St Edmund Hall, Oxford
- Margerie Venables Taylor, first female vice-president of the Society of Antiquaries of London
- Claire Tomlinson, highest-rated female polo player, first woman to win the County Cup and the Queen's Cup, first woman in the world to rise to five goals, first female player in The Varsity Polo Match and first female captain of the OUPC
- Lady Juliet Townsend, first female Lord Lieutenant of Northamptonshire
- Anne Treisman, first woman to win the Golden Brain Award
- Pamela Vandyke-Price, first British woman to write about wine and spirits
- Marcia Wilkinson, first recipient of the Elizabeth Garrett Anderson Award for her extraordinary contribution to relieving the burden of those affected by headache
- Jean Wilks, first female Pro-Chancellor of Birmingham University
- Audrey Williams, first woman president of the Royal Institution of South Wales
- Shirley Williams, Baroness Williams of Crosby, first woman chair of the Oxford University Labour Club and first SDP MP
- Dorothy Maud Wrinch, first female Lecturer in Mathematics at Oxford and first woman to receive an Oxford DSc
- Mai Yamani, first Saudi Arabian woman to obtain a M.St. and a D.Phil. from Oxford
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