This is a list of notable people from Cheb or Eger.
- Zdenka Becker [de] (born 1951), Czechoslovak-Austrian writer
- Frank Boldt [cz] (1942–2006), German historian, Slavic scholar and translator
- Jaromír Bosák [cz] (born 1965), Czech sports commentator and journalist
- Johann Georg Franz Braun [de] (before 1638–1670), cantor at St. Nicholas, composer, author of Ave Maria zart
- Bretislav III (–1197), Czech prince and bishop of Prague's Přemyslid dynasty
- Balthasar Brusch [de] (1512–1589), German bookbinder and bookseller, author of the city history and family chronicles
- Kaspar Brusch [de] (1518–1559), German humanist, poet and, historian, went to school in Eger
- Andreas Buberl [de] (1832–1907), German military doctor, spa doctor, honorary citizen of Eger and Franzensbad
- Martin Fenin (born 1987), Czech footballer
- Adolf Fischer (born 1925), German family and local historian, went to school in Eger
- Helmut Lederer [de] (1919–1999), German sculptor and photographer
- Abraham Leuthner [de] (ca. 1639–1701), mason and builder, built the Dominican church and monastery in Cheb
- Erich Riedl (born 1933), German CSU politician, member of the German Bundestag
- Barbara Schack (1873/4–1958) Sudeten German politician (DSAP)
- Adolf Scherbaum (1909–2000), German trumpeter
- Johann Adam Schertzer [de] (1628–1683), German Protestant theologian
- Kaspar Schlick [de] (ca. 1396–1449), Chancellor of three kings and Chancellor under Emperor Sigismund, a politically important personality of the first half of the 15th century
- Walther Schuster [de] (1930–1992), German organist and composer
- Otmar Seidl [de] (born 1944), German internist, psychoanalyst and sociologist
- Rudolf Serkin (1903–1991), American pianist of Russian-Jewish origin
- Kurt Sieber [de] (born 1936), German politician (FDP)
- Karl Siegl [de] (1851–1943), historian, German city archivist and museum director
- Norbert Singer (born 1939), German automotive engineer responsible for many of Porsche's victories at the 24 Hours of Le Mans races
- Rüdiger von Sparneck [de] (~1300–1364/1368), Viscount of Eger
- Hans Stanka (1864–1936), President of the Deutsche Feuerwehr in Böhmen (German fire department in Bohemia)
- Lorenz Johann Adam Köstler von Stromberg [de] (1807–1888), Fountain doctor and honorary citizen of Franzensbad and Eger
- Heribert Sturm [de] (1904–1981), German city archivist and museum director
- Albrecht von Wallenstein (1583–1634), Bohemian military leader and politician during the Thirty Years' War
- Johannes Watzal [de] (1887–?), German sculptor
- Josef Weidl [de] (1915–1972), Sudeten German sculptor
- Elisabeth Wicki-Endriss [de] (born 1944), German actress, widow of Bernhard Wicki
- Johannes Widmann (1460–after 1498), German mathematician
- Karl Wilfert (1879–1932), German sculptor
- Adam Wolf [de] (1822–?), Austrian historian
- Gerd Wolf [de] (born 1933), German physicist
- Karl Hermann Wolf (1862–1941), journalist and German national politician