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This is a list of rivers in the United States that have names starting with the letter S. For the main page, which includes links to listings by state, see List of rivers in the United States.
- Sabine River - Texas, Louisiana
- Sac River - Missouri
- Sacagawea River - Montana
- Sacandaga River - New York
- Saco River - New Hampshire, Maine
- Sacramento River - California
- Saddle River - New York, New Jersey
- Sagavanirktok River - Alaska
- Saginaw River - Michigan
- St. Clair River - Michigan
- St. Croix River - Maine
- St. Croix River - Wisconsin, Minnesota
- St. Francis River - Maine
- St. Francis River - Minnesota
- St. Francis River - Missouri, Arkansas
- St. Joe River - Idaho
- St. John River - Maine
- St. Johns River - Florida
- St. Jones River - Delaware
- St. Joseph River (Lake Michigan) - Michigan, Indiana
- St. Joseph River (Maumee River) - Michigan, Ohio, Indiana
- St. Lawrence River - New York
- St. Louis River - Minnesota, Wisconsin
- St. Lucie River - Florida
- St. Maries River - Idaho
- St. Marks River - Florida
- St. Martin River - Maryland
- St. Mary River - Montana
- St. Marys River - Florida, Georgia
- St. Marys River - Indiana, Ohio
- St. Marys River - Maryland
- St. Marys River - Michigan
- St. Regis River - Montana
- St. Regis River - New York
- St. Vrain Creek or St. Vrain River - Colorado
- Sakonnet River - Rhode Island