Manuel Isidro Orozco Manrique de Lara (1681–1745) was a Spanish bishop who served as Grand Inquisitor of Spain from 1742 to 1745.
Manuel Isidro Orozco Manrique de Lara was born in Madrid on 15 May 1681.[1] He was appointed Bishop of Jaén on 21 July 1732 and was consecrated as a bishop by Cardinal Diego de Astorga y Céspedes on 9 October 1732.[1] He was translated to the Archdiocese of Santiago de Compostela on 5 May 1738.[1] He became Grand Inquisitor of Spain on 1 January 1742.[2] He died on 10 January 1745.[2]