The first school in Midwest was built on Lewis Street in September 1921, where Mrs. Helen Wallace taught 32 students in one room. It was torn down in 1927.[9]
The new high school was constructed and furnished by the end of 1924 and opened on the first Monday of 1925.[10][11] Twelve seniors graduated in June 1925.[12]
In 1925, the Midwest Refinery Company set up night lighting at the school for a football game played by Midwest High School.[13]
Midwest High School was torn down in 1960 and the new high school was built in 1961,[9] supported by a series of bod issues beginning in 1958.[14][15][16][17][18][19][20][21]
Midwest School was evacuated and closed for 18 months over a volatile organic compound gas leak from an oil well in 2016.[22] Air quality tests performed by the government concluded 200 times the amount of benzene considered safe for humans was present. Students were forced to commute 42 miles daily to Casper in order to attend classes, taking a toll not only on students but also on the community as a whole, as the school represented the "heart" of the community. The school district was forced to hire an environmental consultant and work with state and federal health agencies to ensure the return of students would not induce long-term health issues.[23] Students returned to classes at the school in the fall of 2018 after the area was cleared.[4][24]
In 2022, the school was rated to have met some standards by the Wyoming Department of Education.[25] The district graduation rate had increased to a seven-year high of 80.3% in 2020-2021.[26] However, both Midwest 3–8 and Midwest High School were listed as falling short of state standards in the 2021-2022 school year in the Natrona County report.[27]