Mill Creek is a stream in southwestern Madison County and the northwest corner of Wayne County in the U.S. state of Missouri.[1] It is a tributary of Crane Pond Creek.
The stream headwaters arise in Madison County at 37°22′01″N 90°32′51″W / 37.36694°N 90.54750°W and the stream flows south to its confluence with Crane Pond Creek in the northwest corner of Wayne County at 37°18′49″N 90°32′38″W / 37.31361°N 90.54389°W.[1] The community of Brunot lies just west of the stream junction.[2]
Mill Creek received its name on account of a gristmill on its course.[3]