N-acetylglucosamine deacetylase

From Wikipedia - Reading time: 6 min

N-acetylglucosamine deacetylase
Identifiers
EC no.3.5.1.33
CAS no.9012-32-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a N-acetylglucosamine deacetylase (EC 3.5.1.33) is an enzyme that catalyzes the chemical reaction

N-acetyl-D-glucosamine + H2O D-glucosamine + acetate

Thus, the two substrates of this enzyme are N-acetyl-D-glucosamine and H2O, whereas its two products are D-glucosamine and acetate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-acetyl-D-glucosamine amidohydrolase. Other names in common use include acetylaminodeoxyglucose acetylhydrolase, and N-acetyl-D-glucosaminyl N-deacetylase. This enzyme participates in aminosugars metabolism.

Structural studies

[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2C1G and 2C1I.

References

[edit]
  • Roseman S (May 1957). "Glucosamine metabolism. I. N-acetylglucosamine deacetylase". The Journal of Biological Chemistry. 226 (1): 115–24. doi:10.1016/S0021-9258(18)64810-0. PMID 13428742.



Licensed under CC BY-SA 3.0 | Source: https://en.wikipedia.org/wiki/N-acetylglucosamine_deacetylase
2 views |
Download as ZWI file
Encyclosphere.org EncycloReader is supported by the EncyclosphereKSF