NAV2

NAV2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2YRN
Identifiers
Aliases	NAV2, HELAD1, POMFIL2, RAINB1, STEERIN2, UNC53H2, neuron navigator 2
External IDs	OMIM: 607026; MGI: 2183691; HomoloGene: 52330; GeneCards: NAV2; OMA:NAV2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	20,121,601 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	49,610,090 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; tail of epididymis; ; corpus epididymis; ; visceral pleura; ; internal globus pallidus; ; bronchial epithelial cell; ; caput epididymis; ; oocyte; ; epithelium of lactiferous gland; ; medulla oblongata;
	Top expressed in
	zygote; ; ascending aorta; ; granular layer; ; aortic valve; ; cardiac muscle tissue of left ventricle; ; secondary oocyte; ; choroid plexus of fourth ventricle; ; extraocular muscle; ; plantaris muscle; ; extensor digitorum longus muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; heparin binding; protein binding; ATP binding; hydrolase activity; helicase activity;
Cellular component	interstitial matrix; nucleus; nucleoplasm; extracellular matrix;
Biological process	vagus nerve development; sensory perception of smell; glossopharyngeal nerve development; regulation of systemic arterial blood pressure by baroreceptor feedback; hearing; locomotory behavior; optic nerve development; nervous system development; neurogenesis;
	Sources:Amigo / QuickGO
Orthologs
	89797
	78286
	ENSG00000166833
	ENSMUSG00000052512
	Q8IVL1
	n/a
	NM_001111018; NM_001111019; NM_001244963; NM_145117; NM_182964
	NM_001111016; NM_175272
	NP_001104488; NP_001104489; NP_001231892; NP_660093; NP_892009
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Neuron navigator 2 is a protein that in humans is encoded by the NAV2 gene.^[5]^[6]^[7] The vitamin A metabolite, all-trans retinoic acid (atRA), plays an important role in neuronal development, including neurite outgrowth. NAV2 is an atRA-responsive gene.^[7]

The neuron navigator, Is also theorized to play a role in cellular growth and migration.^[8] In addition, different isoform variants have been discovered for this gene. Connections have been drawn to Nav2 having an association with human neurocognitive disorders Alzheimer's disease and age-related phenotypes. It has been discussed that future studies of Nav2 could provide crucial information in understanding the pathophysiology of the disease and its related phenotypes.^[9]

NAV2 association

The NAV2 gene, which is extensively expressed in the brain and is important to nervous system development, may play a role in Alzheimer's disease.^[10] Alzheimer's disease is a chronic neurological illness whose prevalence rises rapidly as people reach the age of 65. According to reports, Alzheimer's disease is one of the top ten main causes of death in the United States.There are 50 introns and 38 exons in the neuron navigator 2 (NAV2) gene.^[10] The NAV2 gene was shown to be strongly expressed in the brain, as well as the kidney, liver, thyroid, mammary gland, and spinal cord (and may be involved in cell proliferation, migration, and nervous system development).^[10] NAV2 has recently been linked to episodic memory scores in Alzheimer's patients.To date, no study has looked into the link between the NAV2 gene and the risk or AAO of Alzheimer's disease.^[10] NAV2 may be one of the processes linking blood pressure, cardiovascular disease, and neurodegenerative disorders, according to this study. NAV2 was found to be overexpressed in human colorectal cancer in another gene expression analysis, suggesting that it could be used as a predictive biomarker as well as a possible therapeutic target for colorectal cancer. However, the conducted study may have some limitations, so more research is needed to adequately understand the purpose of NAV2.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166833 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052512 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maes T, Barcelo A, Buesa C (Jun 2002). "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans". Genomics. 80 (1): 21–30. doi:10.1006/geno.2002.6799. PMID 12079279.
^ Coy JF, Wiemann S, Bechmann I, Bachner D, Nitsch R, Kretz O, Christiansen H, Poustka A (Jun 2002). "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms". Gene. 290 (1–2): 73–94. doi:10.1016/S0378-1119(02)00567-X. PMID 12062803.
^ ^a ^b "Entrez Gene: NAV2 neuron navigator 2".
^ "NAV2 neuron navigator 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-05-05.
^ Xu C, Su BB, Lozano S, Wang K (2020-01-01), Martin CR, Preedy VR (eds.), "Chapter 1 - The neuron navigator 2 gene and Alzheimer's disease", Genetics, Neurology, Behavior, and Diet in Dementia, Academic Press, pp. 3–24, ISBN 978-0-12-815868-5, retrieved 2022-05-05
^ ^a ^b ^c ^d ^e Wang KS, Liu Y, Xu C, Liu X, Luo X (2017-09-15). "Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease". Journal of Neuroimmunology. 310: 60–65. doi:10.1016/j.jneuroim.2017.06.010. ISSN 0165-5728. PMC 6167010. PMID 28778446.

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Xu C, Su BB, Lozano S, Wang K (2020-01-01), Martin CR, Preedy VR (eds.), "Chapter 1 - The neuron navigator 2 gene and Alzheimer's disease", Genetics, Neurology, Behavior, and Diet in Dementia, Academic Press, pp. 3–24, ISBN 978-0-12-815868-5, retrieved 2022-05-05
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Merrill RA, Plum LA, Kaiser ME, Clagett-Dame M (2002). "A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3422–7. Bibcode:2002PNAS...99.3422M. doi:10.1073/pnas.052017399. PMC 122539. PMID 11904404.
Ishiguro H, Shimokawa T, Tsunoda T, et al. (2002). "Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas". Oncogene. 21 (41): 6387–94. doi:10.1038/sj.onc.1205751. PMID 12214280. S2CID 20205673.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
Tsutsumi S, Kamata N, Vokes TJ, et al. (2004). "The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC 1182089. PMID 15124103.
Peeters PJ, Baker A, Goris I, et al. (2004). "Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53". Brain Res. Dev. Brain Res. 150 (2): 89–101. doi:10.1016/j.devbrainres.2004.03.004. PMID 15158073.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166833 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052512 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12079279-5] Maes T, Barcelo A, Buesa C (Jun 2002). "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans". Genomics. 80 (1): 21–30. doi:10.1006/geno.2002.6799. PMID 12079279.

[pmid12062803-6] Coy JF, Wiemann S, Bechmann I, Bachner D, Nitsch R, Kretz O, Christiansen H, Poustka A (Jun 2002). "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms". Gene. 290 (1–2): 73–94. doi:10.1016/S0378-1119(02)00567-X. PMID 12062803.

[entrez-7] "Entrez Gene: NAV2 neuron navigator 2".

[8] "NAV2 neuron navigator 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-05-05.

[9] Xu C, Su BB, Lozano S, Wang K (2020-01-01), Martin CR, Preedy VR (eds.), "Chapter 1 - The neuron navigator 2 gene and Alzheimer's disease", Genetics, Neurology, Behavior, and Diet in Dementia, Academic Press, pp. 3–24, ISBN 978-0-12-815868-5, retrieved 2022-05-05

[Alzheimer_2017-10] Wang KS, Liu Y, Xu C, Liu X, Luo X (2017-09-15). "Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease". Journal of Neuroimmunology. 310: 60–65. doi:10.1016/j.jneuroim.2017.06.010. ISSN 0165-5728. PMC 6167010. PMID 28778446.

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NAV2

NAV2 association

References

Further reading