Protein-coding gene in the species Homo sapiens
Phosphatidylinositol 4-kinase alpha is an enzyme that in humans is encoded by the PI4KA gene .[ 5] [ 6] [ 7]
This gene encodes a 1-phosphatidylinositol 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate . The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine . Two transcript variants encoding different isoforms have been described for this gene.[ 7]
Clinical significance [ edit ] The alpha isoform of PI4KIII plays a role in replication of hepatitis C virus (HCV).[ 8] NS5A protein.[ 9]
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Activity Regulation Classification Kinetics Types
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