Pantetheine hydrolase

Structure of the pantetheinase vanin-1 from PDB: 4CYF​. Catalytic residues and sugars are shown in sticks, sugar-binding residues in lines.
Identifiers
EC no.	3.5.1.92
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
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PDB structures	RCSB PDB PDBe PDBsum
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In enzymology, a pantetheine hydrolase (EC 3.5.1.92) is an enzyme that catalyzes the chemical reaction

(R)-pantetheine + H₂O ${\displaystyle \rightleftharpoons }$ (R)-pantothenate + 2-aminoethanethiol

Thus, the two substrates of this enzyme are (R)-pantetheine and H₂O, whereas its two products are (R)-pantothenate and 2-aminoethanethiol.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is (R)-pantetheine amidohydrolase. Other names in common use include pantetheinase, vanin, and vanin-1. This enzyme participates in pantothenate and CoA biosynthesis.

• Dupre S, Cavallini D (1979). "Purification and properties of pantetheinase from horse kidney". Vitamins and Coenzymes Part D. Methods in Enzymology. Vol. 62. pp. 262–7. doi:10.1016/0076-6879(79)62227-9. ISBN 978-0-12-181962-0. PMID 440106.
• Dupre S, Chiaraluce R, Nardini M, Cannella C, Ricci G, Cavallini D (1984). "Continuous spectrophotometric assay of pantetheinase activity". Anal. Biochem. 142 (1): 175–81. doi:10.1016/0003-2697(84)90534-7. PMID 6549111.
• Maras B, Barra D, Dupre S, Pitari G (1999). "Is pantetheinase the actual identity of mouse and human vanin-1 proteins?". FEBS Lett. 461 (3): 149–52. Bibcode:1999FEBSL.461..149M. doi:10.1016/S0014-5793(99)01439-8. PMID 10567687.
• P; Galland, F; Bazin, H; Zakharyev, VM; Imhof, BA; Naquet, P (1996). "Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing". Immunity. 5 (5): 391–405. doi:10.1016/S1074-7613(00)80496-3. PMID 8934567.
• Maras B, Dupre S, Naquet P, Galland F (2000). "Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice". FEBS Lett. 483 (2–3): 149–54. Bibcode:2000FEBSL.483..149P. doi:10.1016/S0014-5793(00)02110-4. PMID 11042271.
• Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F (2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics. 53 (4): 296–306. doi:10.1007/s002510100327. PMID 11491533.
• Pace HC, Brenner C (2001). "The nitrilase superfamily: classification, structure and function". Genome Biol. 2 (1): REVIEWS0001. doi:10.1186/gb-2001-2-1-reviews0001. PMC 150437. PMID 11380987.

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