Pharmacological dissection

Pharmacological dissection discriminates among varieties of superficially similar disorders or syndromes by their differential response to a drug.^[1]

The term was introduced in 1957,^[2] and popularized in psychopharmacology by Donald Klein.^[3]

Notes

^ BehaveNet, s.v. pharmacological dissection
^ William A. Spencer, "Factors of Significance in the Respiratory System", Annals of the New York Academy of Sciences 66:4:891-930 (April 1957) doi:10.1111/j.1749-6632.1957.tb40777.x "The data on which this concept is based were obtained by experimental ablation of the brainstem in dogs and by pharmacological "dissection" of the patterning of respiration with morphine and dl-Dromoran."
^ Donald Klein, "Anxiety reconceptualized: Gleaning from pharmacological dissection: Early experience with imipramine and anxiety" Modern problems of pharmacopsychiatry, 1987

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[1] BehaveNet, s.v. pharmacological dissection

[2] William A. Spencer, "Factors of Significance in the Respiratory System", Annals of the New York Academy of Sciences 66:4:891-930 (April 1957) doi:10.1111/j.1749-6632.1957.tb40777.x "The data on which this concept is based were obtained by experimental ablation of the brainstem in dogs and by pharmacological "dissection" of the patterning of respiration with morphine and dl-Dromoran."

[3] Donald Klein, "Anxiety reconceptualized: Gleaning from pharmacological dissection: Early experience with imipramine and anxiety" Modern problems of pharmacopsychiatry, 1987

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