"Pople" is an Anglo-Dutch surname from a local name in Belgium (Poppel), it is pronounced POPE-el. Notable people with this surname include:
- Anthony Pople (1955–2003), British musicologist and writer
- John Pople (1925–2004), British theoretical chemist and Nobel laureate
- Luke Pople (born 1991), Australian wheelchair basketball player
- Robert Pople (1836–1909), British publican and Mayor of Exeter
- Rodney Pople (born 1952), Australian visual artist
- Ross Pople (born 1945), New Zealand-born British conductor and classical cellist