Sandovo railway station was open in 1919.[10] At the time, it belonged to Vesyegonsky Uyezd of Tver Governorate. The station was named after the selo of Sandovo, however, it was located far from the selo. The closest village to the station was Orudovo.
On April 25, 1921, Vesyegonsky Uyezd was transferred to newly established Rybinsk Governorate. On February 15, 1923, Rybinsk Governorate was abolished, and the uyezd was transferred back to Tver Governorate.[11]
On July 12, 1929 the governorates and uyezds were abolished. Sandovsky District, with the administrative center in the selo of Sandovo, was established within Bezhetsk Okrug of Moscow Oblast. On July 23, 1930, the okrugs were abolished, and the districts were directly subordinated to the oblast.[11] In 1932, the district center was transferred to the village of Orudovo, which eventually grew up as the settlement of Sandovo. Simultaneously, the selo of Sandovo was renamed Staroye Sandovo.[3] On January 29, 1935 Kalinin Oblast was established, and Sandovsky District was transferred to Tver Oblast. In February 1963, during the abortive Khrushchyov administrative reform, Sandovsky District was merged into Vesyegonsly District, but in January 1965 it was re-established.[11] In 1967, Sandovo was granted urban-type settlement status.[3]
Sandovo is connected by road with Krasny Kholm via Molokovo. Gravel roads run to Vesyegonsk and Ustyuzhna. There are also local roads, with bus traffic originating from Sandovo.
In the settlement, there is one object classified as cultural heritage of local significance. This is a monument to soldiers fallen in World War II.[13]
In Sandovo, there is a Bee Museum, which shows materials related to beekeeping, a traditional occupation of local peasants. The museum was opened in 2007.[14]
Законодательное Собрание Тверской области. Закон №34-ЗО от 17 апреля 2006 г. «Об административно-территориальном устройстве Тверской области», в ред. Закона №66-ЗО от 1 октября 2014 г. «О внесении изменения в статью 18 Закона Тверской области "Об административно-территориальном устройстве Тверской области"». Вступил в силу со дня официального опубликования. Опубликован: "Тверские ведомости", №17 (специальный выпуск), 19 апреля 2006 г. (Legislative Assembly of Tver Oblast. Law #34-ZO of April 17, 2006 On the Administrative-Territorial Structure of Tver Oblast, as amended by the Law #66-ZO of October 1, 2014 On Amending Article 18 of the Law of Tver Oblast "On the Administrative-Territorial Structure of Tver Oblast". Effective as of the official publication date.).
Законодательное Собрание Тверской области. Закон №44-ЗО от 28 февраля 2005 г. «Об установлении границ муниципальных образований, входящих в состав территории муниципального образования Тверской области "Сандовский район", и наделении их статусом городского, сельского поселения», в ред. Закона №18-ЗО от 28 марта 2013 г. «О преобразовании муниципальных образований Топоровское сельское поселение Сандовского района Тверской области и Старосандовское сельское поселение Сандовского района Тверской области и внесении изменений в Закон Тверской области "Об установлении границ муниципальных образований, входящих в состав территории муниципального образования Тверской области "Сандовский район", и наделении их статусом городского, сельского поселения"». Вступил в силу со дня официального опубликования. Опубликован: "Тверские ведомости", №10, 11–17 марта 2005 г. (Legislative Assembly of Tver Oblast. Law #44-ZO of February 28, 2005 On Establishing the Borders of the Municipal Formations Comprised by the Territory of the Municipal Formation of "Sandovsky District" and on Granting Them the Status of Urban, Rural Settlements, as amended by the Law #18-ZO of March 28, 2013 On the Transformation of the Municipal Formations of Toporovskoye Rural Settlement of Sandovsky District of Tver Oblast and Starosandovskoye Rural Settlement of Sandovsky District of Tver Oblast and on Amending the Law of Tver Oblast "On Establishing the Borders of the Municipal Formations Which the Territory of the Municipal Formation of "Sandovsky District" Comprises and on Granting Them the Status of Urban, Rural Settlements". Effective as of the day of the official publication.).