Succinate—CoA ligase (GDP-forming)

succinate—CoA ligase (GDP-forming)
Pig GTP-specific succinyl-CoA synthetase with GTP. PDB 2fp4 [1]
Identifiers
EC no.	6.2.1.4
CAS no.	9014-36-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a succinate—CoA ligase (GDP-forming) (EC 6.2.1.4) is an enzyme that catalyzes the chemical reaction

GTP + succinate + CoA ${\displaystyle \rightleftharpoons }$ GDP + phosphate + succinyl-CoA

The 3 substrates of this enzyme are GTP, succinate, and CoA, whereas its 3 products are GDP, phosphate, and succinyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is succinate:CoA ligase (GDP-forming). Other names in common use include succinyl-CoA synthetase (GDP-forming), succinyl coenzyme A synthetase (guanosine diphosphate-forming), succinate thiokinase, succinic thiokinase, succinyl coenzyme A synthetase, succinate-phosphorylating enzyme, P-enzyme, SCS, G-STK, succinyl coenzyme A synthetase (GDP-forming), succinyl CoA synthetase, and succinyl coenzyme A synthetase. This enzyme participates in the citric acid cycle and propanoate metabolism.

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1EUC, 1EUD, 2FP4, 2FPG, 2FPI, and 2FPP.

• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 387-399.
• Kaufman S, Gilvarg C, Cori O, Ochoa S (1953). "Enzymatic oxidation of alpha-ketoglutarate and coupled phosphorylation". J. Biol. Chem. 203 (2): 869–888. doi:10.1016/S0021-9258(19)52356-0. PMID 13084656.
• Mazumder R, Sanadi DR, Rodwell WV (1960). "Purification and properties of hog kidney succinic thiokinase". J. Biol. Chem. 235 (9): 2546–2550. doi:10.1016/S0021-9258(19)76911-7. PMID 13768680.
• SANADI DR, GIBSON M, AYENGAR P (1954). "Guanosine triphosphate, the primary product of phosphorylation coupled to the breakdown of succinyl coenzyme A". Biochim. Biophys. Acta. 14 (3): 434–6. doi:10.1016/0006-3002(54)90205-X. PMID 13181903.