TRIP6

TRIP6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X61, 2DLO
Identifiers
Aliases	TRIP6, OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1, thyroid hormone receptor interactor 6
External IDs	OMIM: 602933; MGI: 1343458; HomoloGene: 37757; GeneCards: TRIP6; OMA:TRIP6 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,873,454 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,312,666 bp
RNA expression pattern
	Top expressed in
	body of uterus; ; right lobe of thyroid gland; ; palpebral conjunctiva; ; canal of the cervix; ; left uterine tube; ; nipple; ; ectocervix; ; left lobe of thyroid gland; ; ascending aorta; ; gastric mucosa;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; vas deferens; ; condyle; ; ascending aorta; ; efferent ductule; ; aortic valve; ; fossa; ; vestibular membrane of cochlear duct; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kinase binding; protein binding; interleukin-1 receptor binding; metal ion binding; thyroid hormone receptor binding; RNA binding;
Cellular component	cell junction; plasma membrane; interleukin-1 receptor complex; cytoskeleton; nucleus; focal adhesion; cytoplasm; cytosol; stress fiber;
Biological process	focal adhesion assembly; cell adhesion; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of cell migration; positive regulation of NIK/NF-kappaB signaling; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7205
	22051
	ENSG00000087077
	ENSMUSG00000023348
	Q15654
	Q9Z1Y4
	NM_003302
	NM_011639
	NP_003293
	NP_035769
	Wikidata
View/Edit Human	View/Edit Mouse

Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.^[5]^[6]^[7]

Function

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[7]

Interactions

TRIP6 has been shown to interact with LPAR2,^[8] BCAR1^[8]^[9] and HOXA9.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087077 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023348 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yi J, Beckerle MC (Apr 1998). "The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis". Genomics. 49 (2): 314–6. doi:10.1006/geno.1998.5248. PMID 9598321.
^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Feb 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Molecular Endocrinology. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.
^ ^a ^b "Entrez Gene: TRIP6 thyroid hormone receptor interactor 6".
^ ^a ^b Xu J, Lai YJ, Lin WC, Lin FT (Mar 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". The Journal of Biological Chemistry. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMC 3904432. PMID 14688263.
^ Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC (Mar 2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". The Journal of Biological Chemistry. 277 (11): 9580–9. doi:10.1074/jbc.M106922200. PMID 11782456.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

Overview of all the structural information available in the PDB for UniProt: Q15654 (Thyroid receptor-interacting protein 6) at the PDBe-KB.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087077 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023348 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9598321-5] Yi J, Beckerle MC (Apr 1998). "The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis". Genomics. 49 (2): 314–6. doi:10.1006/geno.1998.5248. PMID 9598321.

[pmid7776974-6] Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Feb 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Molecular Endocrinology. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.

[entrez-7] "Entrez Gene: TRIP6 thyroid hormone receptor interactor 6".

[pmid14688263-8] Xu J, Lai YJ, Lin WC, Lin FT (Mar 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". The Journal of Biological Chemistry. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMC 3904432. PMID 14688263.

[pmid11782456-9] Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC (Mar 2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". The Journal of Biological Chemistry. 277 (11): 9580–9. doi:10.1074/jbc.M106922200. PMID 11782456.

[pmid16189514-10] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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TRIP6

Function

Interactions

References

Further reading

External links