The movie is all about four men who have been together since high school. It is based on a true story. They treat each other as brothers. When they graduated in college and started to live the "real life", they found out that something is missing. There is a specific aspect in their lives that need some changes so they can move forward and continue living the kind of lives they ever dreamed of. To do this, they have to go back to their past and re-examine all the things they did. All the questions they have in their minds started when they attended their high school reunion. Since that night, their lives have started to change.
Enchong Dee as Lloyd Alvarado - The hopeless romantic of the group and now a graphic artist. He thought that all of his friends' karma comes from when they cheated on their respective first love when they were in high school. His first love is Ara (Cristine Reyes), who is now engaged and he plans to find her in hopes of winning her back. But along his journey, he finally realized that he loves his best friend, Ali (Jessy Mendiola).
Xian Lim as Joaquin "Joax" Zabala - He is a valet at a hotel. He has high aspirations in life. He found Toyang (Megan Young), who is now a nurse, and learns that Toyang got pregnant and he is the father. Now he is enjoying the company of his son until he goes to Canada with Toyang and her fiance.
Enrique Gil as Boggs Alvarez - The playboy of the group. He is working as a real-estate agent. But of all of the girls he met, he is still in love with Ligaya (Julia Montes) and will do anything to find her and win her heart again. A year later, he and Ligaya got married.
Kean Cipriano as Patrick "Pat" dela Torre - He wants to be in a band and to be famous someday. He found out that Shirley (Bangs Garcia), his first love who is conservative when they were in high school, is now a bikini model and he feels guilty about it. But their love is rekindled one more time.
Jessy Mendiola as Allison "Ali" Marasigan - Lloyd's best friend who secretly has a crush on him. She wants the best for her best friend and encouraged him to apply in Singapore. Lloyd realized later on that he loves Ali and follows her at the airport before she leaves for a job in Singapore.
Megan Young as Antonia "Toyang" Castro - She is Joax' ex-girlfriend. She is a nurse and had a son, Miggy and Joax is the father. She didn't tell him about Miggy because when he lied about her not being pregnant, Joax was so happy. She is now going to Canada with his son and fiance. But she allowed Joax to be with Miggy for quite some time.
Julia Montes as Ligaya Bustamante - She and Boggs met when Boggs hit her with a ball in the head. Their love story began here but when she found out that all of Boggs' friends including him is in Julie's car, she got jealous and they broke up. Boggs found her in Laguna in her family's cafe but found out that she got in an accident when she attempted to climb the Hill of Tears alone, resulting in her left leg being amputated. Boggs loves her so much that he didn't mind it and told her that she is the perfect girl for him.
Bangs Garcia as Shirley Suarez - She is the conservative girlfriend of Pat. She is left heartbroken because of what her boyfriend did. She became a model and Pat feels guilty because he thought that that was all his fault. Shirley forgives him and they got back together.
Cristine Reyes as Ara Reyes - He is Lloyd's first love, she forgave and forget what Lloyd did to her when they were still together. She is now engaged, and Lloyd tried to find her in hopes of winning her back again.
Matt Evans as Jay Lopez - He is Ali's gay best friend and knows that Ali likes Lloyd. He is a great friend for Ali and always wants the best for her.
Alexa Ilacad as Marie Suarez - Shirley's younger sister
Gina Pareño as Aling Nena - she owns a store that Lloyd, Boggs, Joax, and Pat hang when they were in high school. He bailed the boys out of jail.
Janus Del Prado as Huweyingnon (Wellington) - he got in a car accident because of Joax and he is the reason Joax found Toyang when they brought him to the hospital.
Some of the characters' names are from Eraserheads' songs like Toyang (Toyang), Shirley, Ligaya (Ligaya), Ali (Alapaap), Julie (Julie Tearjerky), Aling Nena (Tindahan ni Aling Nena), Ning Ning (Paro Parung Ningning), and Jay (Hey Jay).
The school was named as Padre Orlando Prudenciano University or Pop U! which was taken from the E heads unofficial album or a sample demo.
Joax, Lloyd, Jay and Ali checked into a hotel called Andalusian Hotel (taken from the Eraserheads song "Andalusian Dog").
The scene where Miggy (Louise Abuel) and Joax (Xian Lim) play the piano was inspired by the Eraserheads album Sticker Happy.