VAMP4

VAMP4
Identifiers
Aliases	VAMP4, VAMP-4, VAMP24, vesicle associated membrane protein 4
External IDs	OMIM: 606909; MGI: 1858730; HomoloGene: 37847; GeneCards: VAMP4; OMA:VAMP4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	171,742,074 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	162,426,653 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; dorsal motor nucleus of vagus nerve; ; inferior olivary nucleus; ; pons; ; pars compacta; ; lateral nuclear group of thalamus; ; cerebellar vermis; ; tibia;
	Top expressed in
	gastrula; ; supraoptic nucleus; ; pituitary gland; ; motor neuron; ; decidua; ; Epithelium of choroid plexus; ; dorsomedial hypothalamic nucleus; ; lateral septal nucleus; ; islet of Langerhans; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	SNAP receptor activity; protein binding; SNARE binding;
Cellular component	integral component of membrane; cell surface; Golgi membrane; endosome; Golgi apparatus; lysosome; membrane; trans-Golgi network membrane; SNARE complex; transport vesicle; plasma membrane; clathrin-coated vesicle membrane; integral component of synaptic vesicle membrane; synaptic vesicle;
Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport; Golgi ribbon formation; microtubule cytoskeleton organization; vesicle-mediated transport; SNARE complex assembly; Golgi to plasma membrane protein transport; exocytosis; membrane organization; synaptic vesicle to endosome fusion; regulation of synaptic vesicle endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	8674
	53330
	ENSG00000117533
	ENSMUSG00000026696
	O75379
	O70480
	NM_001185127; NM_003762; NM_201994
	NM_016796; NM_001347125; NM_001356526; NM_001356527
	NP_001172056; NP_003753
	NP_001334054; NP_058076; NP_001343455; NP_001343456
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.^[5]^[6]

Function

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport.^[6]

Interactions

VAMP4 has been shown to interact with AP1M1,^[7] STX6^[8] and STX16.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117533 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026696 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH (Apr 1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments". The Journal of Biological Chemistry. 273 (17): 10317–24. doi:10.1074/jbc.273.17.10317. PMID 9553086.
^ ^a ^b "Entrez Gene: VAMP4 vesicle-associated membrane protein 4".
^ Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Reports. 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. PMC 1326413. PMID 14608369.
^ ^a ^b Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Steegmaier M, Klumperman J, Foletti DL, Yoo JS, Scheller RH (Jun 1999). "Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking". Molecular Biology of the Cell. 10 (6): 1957–72. doi:10.1091/mbc.10.6.1957. PMC 25394. PMID 10359608.
Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH (May 2000). "SNAREs contribute to the specificity of membrane fusion". Neuron. 26 (2): 457–64. doi:10.1016/S0896-6273(00)81177-0. PMID 10839363.
Peden AA, Park GY, Scheller RH (Dec 2001). "The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding". The Journal of Biological Chemistry. 276 (52): 49183–7. doi:10.1074/jbc.M106646200. PMID 11598115.
Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.
Zeng Q, Tran TT, Tan HX, Hong W (Jun 2003). "The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network". The Journal of Biological Chemistry. 278 (25): 23046–54. doi:10.1074/jbc.M303214200. PMID 12682051.
Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Reports. 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. PMC 1326413. PMID 14608369.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117533 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026696 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9553086-5] Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH (Apr 1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments". The Journal of Biological Chemistry. 273 (17): 10317–24. doi:10.1074/jbc.273.17.10317. PMID 9553086.

[entrez-6] "Entrez Gene: VAMP4 vesicle-associated membrane protein 4".

[pmid14608369-7] Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Reports. 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. PMC 1326413. PMID 14608369.

[pmid11839770-8] Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.

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VAMP4

Function

Interactions

References

Further reading