Motexafin Lutetium

Motexafin lutetium

Names
Other names Antrin; Lu texaphyrin; Lu-Tex; Lutetium texaphyrin; Lutrin; Optrin; PCI 0123
Identifiers
CAS Number	246252-04-0 Y
3D model (JSmol)	Interactive image
PubChem CID	3081907
UNII	0V38NF6N89 Y
SMILES CC([O-])=O.CCC1=C2[N-]C(/C=C3N=C(/C=N/C4=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C4/N=C/C(C(C)=C/5CCCO)=[N]([Lu+3])C5=C/2)C(C)=C\3CCCO)=C1CC
Properties
Chemical formula	C52H72LuN5O14
Molar mass	1166.136 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Motexafin lutetium is a texaphyrin, marketed as Antrin by Pharmacyclics Inc.

It is a photosensitiser for use in photodynamic therapy to treat skin conditions and superficial cancers.

It has also been tested for use in photoangioplasty (photodynamic treatment of diseased arteries).^[1]

It is photoactivated by 732 nm light which allows greater depth of penetration.^[2]

Clinical trials

Phase II clinical trials were in progress in 1999.^[3]

A phase I trial for prostate cancer reported in 2009.^[4]

References

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