S-(Hydroxymethyl)Glutathione Synthase
From Handwiki | S-(hydroxymethyl)glutathione synthase | |||||||||
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| Identifiers | |||||||||
| EC number | 4.4.1.22 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme S-(hydroxymethyl)glutathione synthase (EC 4.4.1.22) catalyzes the reaction
- S-(hydroxymethyl)glutathione [math]\displaystyle{ \rightleftharpoons }[/math] glutathione + formaldehyde
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming). Other names in common use include glutathione-dependent formaldehyde-activating enzyme, Gfa, and S-(hydroxymethyl)glutathione formaldehyde-lyase. This enzyme participates in methane metabolism.
References
- "A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy". The Journal of Biological Chemistry 277 (5): 3069–72. February 2002. doi:10.1074/jbc.C100579200. PMID 11741920.
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Categories: [EC 4.4.1] [Enzymes of unknown structure]
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☰ Source: https://handwiki.org/wiki/Biology:S-(hydroxymethyl)glutathione_synthase | License: CC BY-SA 3.0
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