Dopamine Receptor

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Dopamine receptors are "cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells."[1]

Classification[edit]

D1-like receptors[edit]

These receptors stimulate adenylate cyclase.[2]

D1 receptors[edit]

D5 receptors[edit]

D2-like receptors[edit]

These receptors inhibit adenylate cyclase.[3]

Dopamine D2 receptors[edit]

Agonists, such as metoclopramide, are used as antiemetics.

Antagonists, such as risperidone and haloperidol, are used to treat schizophrenia.[4]

Blockade of the D2 receptors, which may be predisposed by genetic polymorphisms of the allele, may cause neuroleptic malignant syndrome.[5]

D3 receptors[edit]

Agonists of D3, especially nonergot agonists such as pramipexole and ropinirole, may be used to treat Parkinonism and restless legs syndrome.[6]

D4 receptors[edit]

Novelty seeing personality trait may be related to polymorphisms in the dopamine receptor D4 that affects dopamine activity in the tuberoinfundibular dopaminergic system.[7]

References[edit]

  1. ↑ Anonymous (2025), Receptors, Dopamine (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. ↑ Anonymous (2025), Receptors, Dopamine D1 (English). Medical Subject Headings. U.S. National Library of Medicine.
  3. ↑ Anonymous (2025), Receptors, Dopamine D2 (English). Medical Subject Headings. U.S. National Library of Medicine.
  4. ↑ Katzung, Bertram G. (2001). Basic & clinical pharmacology. New York: Lange Medical Books/McGraw-Hill, 483. ISBN 0-8385-0598-8. 
  5. ↑ Kishida I, Kawanishi C, Furuno T, Kato D, Ishigami T, Kosaka K (2004). "Association in Japanese patients between neuroleptic malignant syndrome and functional polymorphisms of the dopamine D(2) receptor gene". Mol. Psychiatry 9 (3): 293-8. DOI:10.1038/sj.mp.4001422. PMID 15094790. Research Blogging.
  6. ↑ Baker WL, White CM, Coleman CI (2008). "Effect of nonergot dopamine agonists on symptoms of restless legs syndrome". Ann Fam Med 6 (3): 253–62. DOI:10.1370/afm.845. PMID 18474889. Research Blogging.
  7. ↑ Online Mendelian Inheritance in Man, OMIM®. Johns Hopkins University, Baltimore, MD. MIM Number: 601696 . World Wide Web URL: http://omim.org/.
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